Free radicals: Relationship to Human Diseases and Potential Therapeutic applications

被引：45

作者：

Zaric, Bozidarka L. ^{[1
,2
]}

Macvanin, Mirjana T. ^{[1
]}

Isenovic, Esma R. ^{[1
]}

机构：

[1] Univ Belgrade, VINCA Inst Nucl Sci, Natl Inst Republ Serbia, Dept Radiobiol & Mol Genet, Belgrade, Serbia

[2] Univ Belgrade, VINCA Inst Nucl Sci, Natl Inst Republ Serbia, Dept Radiobiol & Mol Genet, POB 522, Belgrade 11000, Serbia

来源：

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY | 2023年 / 154卷

关键词：

Free radicals; Oxidative stress; Nitrosative stress; Mitochondria; Pathophysiological conditions; Reactive oxygen species-modulating; therapeutics; NITRIC-OXIDE SYNTHASE; MITOCHONDRIAL COMPLEX II; ENDOPLASMIC-RETICULUM STRESS; ELECTRON-TRANSPORT CHAIN; OXIDATIVE STRESS; XANTHINE-OXIDASE; HYDROGEN-SULFIDE; LIFE-SPAN; PEROXYNITRITE DECOMPOSITION; CEREBRAL-ISCHEMIA;

D O I：

10.1016/j.biocel.2022.106346

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Reactive species are highly-reactive enzymatically, or non-enzymatically produced compounds with important roles in physiological and pathophysiological cellular processes. Although reactive species represent an exten-sively researched topic in biomedical sciences, many aspects of their roles and functions remain unclear. This review aims to systematically summarize findings regarding the biochemical characteristics of various types of reactive species and specify the localization and mechanisms of their production in cells. In addition, we discuss the specific roles of free radicals in cellular physiology, focusing on the current lines of research that aim to identify the reactive oxygen species-initiated cascades of reactions resulting in adaptive or pathological cellular responses. Finally, we present recent findings regarding the therapeutic modulations of intracellular levels of reactive oxygen species, which may have substantial significance in developing novel agents for treating several diseases.

引用

页数：13

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