The potential of mRNA vaccines in cancer nanomedicine and immunotherapy

被引：21

作者：

Pan, Shulin ^{[1
,2
]}

Fan, Rangrang ^{[3
,4
]}

Han, Bo ^{[5
,6
]}

Tong, Aiping ^{[1
,2
]}

Guo, Gang ^{[1
,2
]}

机构：

[1] Sichuan Univ, West China Hosp, Canc Ctr, Dept Biotherapy, Chengdu 610041, Peoples R China

[2] Sichuan Univ, West China Hosp, State Key Lab Biotherapy, Chengdu 610041, Peoples R China

[3] Sichuan Univ, West China Hosp, Dept Neurosurg, Chengdu 610041, Peoples R China

[4] Sichuan Univ, West China Hosp, Inst Neurosurg, Chengdu 610041, Peoples R China

[5] Shihezi Univ, Sch Pharm, Shihezi 832003, Peoples R China

[6] Minist Educ, Key Lab Xinjiang Phytomed Resource & Utilizat, Shihezi 832002, Peoples R China

来源：

TRENDS IN IMMUNOLOGY | 2024年 / 45卷 / 01期

关键词：

ENHANCES TRANSLATION; CODON OPTIMALITY; IN-VITRO; DELIVERY; PROTEIN; VIRUS; NANOPARTICLES; SYNTHETASE; INDUCTION; FUSION;

D O I：

10.1016/j.it.2023.11.003

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Owing to their outstanding performance against COVID-19, mRNA vaccines have brought great hope for combating various incurable diseases, including cancer. Differences in the encoded proteins result in different molecular and cellular mechanisms of mRNA vaccines. With the rapid development of nanotechnology and molecular medicine, personalized antigen -encoding mRNA vaccines that enhance antigen presentation can trigger effective immune responses and prevent off -target toxicities. Herein, we review new insights into the influence of encoded antigens, cytokines, and other functional proteins on the mechanisms of mRNA vaccines. We also highlight the importance of delivery systems and chemical modifications for mRNA translation efficiency, stability, and targeting, and we discuss the potential problems and application prospects of mRNA vaccines as versatile tools for combating cancer.

引用

页码：20 / 31

页数：12

共 111 条

[1] Patisiran, an RNAi Therapeutic, for Hereditary Transthyretin Amyloidosis [J].

Adams, D. ;

Gonzalez-Duarte, A. ;

O'Riordan, W. D. ;

Yang, C. -C. ;

Ueda, M. ;

Kristen, A. V. ;

Tournev, I. ;

Schmidt, H. H. ;

Coelho, T. ;

Berk, J. L. ;

Lin, K. -P. ;

Vita, G. ;

Attarian, S. ;

Plante-Bordeneuve, V. ;

Mezei, M. M. ;

Campistol, J. M. ;

Buades, J. ;

Brannagan, T. H., III ;

Kim, B. J. ;

Oh, J. ;

Parman, Y. ;

Sekijima, Y. ;

Hawkins, P. N. ;

Solomon, S. D. ;

Polydefkis, M. ;

Dyck, P. J. ;

Gandhi, P. J. ;

Goyal, S. ;

Chen, J. ;

Strahs, A. L. ;

Nochur, S. V. ;

Sweetser, M. T. ;

Garg, P. P. ;

Vaishnaw, A. K. ;

Gollob, J. A. ;

Suhr, O. B. .

NEW ENGLAND JOURNAL OF MEDICINE, 2018, 379 (01) :11-21

[2] Lipid nanoparticles enhance the efficacy of mRNA and protein subunit vaccines by inducing robust T follicular helper cell and humoral responses [J].

Alameh, Mohamad-Gabriel ;

Tombacz, Istvan ;

Bettini, Emily ;

Lederer, Katlyn ;

Sittplangkoon, Chutamath ;

Wilmore, Joel R. ;

Gaudette, Brian T. ;

Soliman, Ousamah Y. ;

Pine, Matthew ;

Hicks, Philip ;

Manzoni, Tomaz B. ;

Knox, James J. ;

Johnson, John L. ;

Laczko, Dorottya ;

Muramatsu, Hiromi ;

Davis, Benjamin ;

Meng, Wenzhao ;

Rosenfeld, Aaron M. ;

Strohmeier, Shirin ;

Lin, Paulo J. C. ;

Mui, Barbara L. ;

Tam, Ying K. ;

Kariko, Katalin ;

Jacquet, Alain ;

Krammer, Florian ;

Bates, Paul ;

Cancro, Michael P. ;

Weissman, Drew ;

Prak, Eline T. Luning ;

Allman, David ;

Locci, Michela ;

Pardi, Norbert .

IMMUNITY, 2021, 54 (12) :2877-+

[3] Intracellular Reverse Transcription of Pfizer BioNTech COVID-19 mRNA Vaccine BNT162b2 In Vitro in Human Liver Cell Line [J].

Alden, Markus ;

Falla, Francisko Olofsson ;

Yang, Daowei ;

Barghouth, Mohammad ;

Luan, Cheng ;

Rasmussen, Magnus ;

De Marinis, Yang .

CURRENT ISSUES IN MOLECULAR BIOLOGY, 2022, 44 (03) :1115-1126

[4] Signatures of mutational processes in human cancer [J].

Alexandrov, Ludmil B. ;

Nik-Zainal, Serena ;

Wedge, David C. ;

Aparicio, Samuel A. J. R. ;

Behjati, Sam ;

Biankin, Andrew V. ;

Bignell, Graham R. ;

Bolli, Niccolo ;

Borg, Ake ;

Borresen-Dale, Anne-Lise ;

Boyault, Sandrine ;

Burkhardt, Birgit ;

Butler, Adam P. ;

Caldas, Carlos ;

Davies, Helen R. ;

Desmedt, Christine ;

Eils, Roland ;

Eyfjord, Jorunn Erla ;

Foekens, John A. ;

Greaves, Mel ;

Hosoda, Fumie ;

Hutter, Barbara ;

Ilicic, Tomislav ;

Imbeaud, Sandrine ;

Imielinsk, Marcin ;

Jaeger, Natalie ;

Jones, David T. W. ;

Jones, David ;

Knappskog, Stian ;

Kool, Marcel ;

Lakhani, Sunil R. ;

Lopez-Otin, Carlos ;

Martin, Sancha ;

Munshi, Nikhil C. ;

Nakamura, Hiromi ;

Northcott, Paul A. ;

Pajic, Marina ;

Papaemmanuil, Elli ;

Paradiso, Angelo ;

Pearson, John V. ;

Puente, Xose S. ;

Raine, Keiran ;

Ramakrishna, Manasa ;

Richardson, Andrea L. ;

Richter, Julia ;

Rosenstiel, Philip ;

Schlesner, Matthias ;

Schumacher, Ton N. ;

Span, Paul N. ;

Teague, Jon W. .

NATURE, 2013, 500 (7463) :415-+

[5] The role of nanoparticle format and route of administration on self-amplifying mRNA vaccine potency [J].

Anderluzzi, Giulia ;

Lou, Gustavo ;

Woods, Stuart ;

Schmidt, Signe Tandrup ;

Gallorini, Simona ;

Brazzoli, Michela ;

Johnson, Russell ;

Roberts, Craig W. ;

O'Hagan, Derek T. ;

Baudner, Barbara C. ;

Perrie, Yvonne .

JOURNAL OF CONTROLLED RELEASE, 2022, 342 :388-399

[6] Nucleoside modifications in RNA limit activation of 2'-5'-oligoadenylate synthetase and increase resistance to cleavage by RNase L [J].

Anderson, Bart R. ;

Muramatsu, Hiromi ;

Jha, Babal K. ;

Silverman, Robert H. ;

Weissman, Drew ;

Kariko, Katalin .

NUCLEIC ACIDS RESEARCH, 2011, 39 (21) :9329-9338

[7] Incorporation of pseudouridine into mRNA enhances translation by diminishing PKR activation [J].

Anderson, Bart R. ;

Muramatsu, Hiromi ;

Nallagatla, Subba R. ;

Bevilacqua, Philip C. ;

Sansing, Lauren H. ;

Weissman, Drew ;

Kariko, Katalin .

NUCLEIC ACIDS RESEARCH, 2010, 38 (17) :5884-5892

[8] Efficacy and Safety of the mRNA-1273 SARS-CoV-2 Vaccine [J].

Baden, Lindsey R. ;

El Sahly, Hana M. ;

Essink, Brandon ;

Kotloff, Karen ;

Frey, Sharon ;

Novak, Rick ;

Diemert, David ;

Spector, Stephen A. ;

Rouphael, Nadine ;

Creech, C. Buddy ;

McGettigan, John ;

Khetan, Shishir ;

Segall, Nathan ;

Solis, Joel ;

Brosz, Adam ;

Fierro, Carlos ;

Schwartz, Howard ;

Neuzil, Kathleen ;

Corey, Larry ;

Gilbert, Peter ;

Janes, Holly ;

Follmann, Dean ;

Marovich, Mary ;

Mascola, John ;

Polakowski, Laura ;

Ledgerwood, Julie ;

Graham, Barney S. ;

Bennett, Hamilton ;

Pajon, Rolando ;

Knightly, Conor ;

Leav, Brett ;

Deng, Weiping ;

Zhou, Honghong ;

Han, Shu ;

Ivarsson, Melanie ;

Miller, Jacqueline ;

Zaks, Tal .

NEW ENGLAND JOURNAL OF MEDICINE, 2021, 384 (05) :403-416

[9] MODULATION OF MEMBRANE-FUSION BY ASYMMETRIC TRANSBILAYER DISTRIBUTIONS OF AMINO LIPIDS [J].

BAILEY, AL ;

CULLIS, PR .

BIOCHEMISTRY, 1994, 33 (42) :12573-12580

[10] An antibody-interleukin 2 fusion protein overcomes tumor heterogeneity by induction of a cellular immune response [J].

Becker, JC ;

Varki, N ;

Gillies, SD ;

Furukawa, K ;

Reisfeld, RA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (15) :7826-7831

← 1 2 3 4 5 6 7 8 9 10 →