Recent research advances in ATX inhibitors: An overview of primary literature

被引：17

作者：

Zhang, Cheng ^{[1
]}

Liu, Yue ^{[1
]}

Zhou, Qinjiang ^{[1
]}

Fan, Hongze ^{[1
]}

Liu, Xiaoxiao ^{[1
]}

Hu, Jinxing ^{[1
]}

机构：

[1] Weifang Med Univ, 7166 Baotong Rd, Weifang 261053, Peoples R China

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2023年 / 90卷

基金：

中国国家自然科学基金;

关键词：

Autotaxin (ATX); Lysophosphatidic acid (LPA); Lysophosphatidylcholine (LPC); Inhibitors; ACID-BASED INHIBITORS; AUTOTAXIN INHIBITOR; BIOLOGICAL EVALUATION; HYDROPHOBIC POCKET; STRUCTURAL BASIS; DISCOVERY; DERIVATIVES; BINDING; LPA; OPTIMIZATION;

D O I：

10.1016/j.bmc.2023.117374

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The autoglobulin gene is the main enzyme for circulating LPA production and has lysophosphatidylcholine D activity, which catalyzes the production of lysophosphatidic acid and choline with lysophosphatidylcholine as substrate. A growing body of experimental evidence suggests that autoglobulin is involved in the pathogenesis of a variety of diseases. This review summarizes the different structural ATX inhibitors classified according to their binding mode to the ATX triple orientation site, and summarizes the conformational relationships and molecular docking of each type with ATX structure, hoping to contribute to the development of novel ATX inhibitors.

引用

页数：19

共 56 条

[1] Substituted 4-phenylthiazoles: Development of potent and selective A1, A3 and dual A1/A3 adenosine receptor antagonists [J].

Abdelrahman, Aliaa ;

Yerande, Swapnil G. ;

Namasivayam, Vigneshwaran ;

Klapschinski, Tim A. ;

Alnouri, Mohamad Wessam ;

El-Tayeb, Ali ;

Mueller, Christa E. .

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2020, 186

[2] Structure-Based Design of Novel Boronic Acid-Based Inhibitors of Autotaxin [J].

Abers, Harald M. H. G. ;

Hendrickx, Loes J. D. ;

van Tol, Rob J. P. ;

Hausmann, Jens ;

Perrakis, Anastassis ;

Ovaa, Huib .

JOURNAL OF MEDICINAL CHEMISTRY, 2011, 54 (13) :4619-4626

[3] Analgesic and Anticancer Activity of Benzoxazole Clubbed 2-Pyrrolidinones as Novel Inhibitors of Monoacylglycerol Lipase [J].

Afzal, Obaid ;

Altamimi, Abdulmalik Saleh Alfawaz ;

Shahroz, Mir Mohammad ;

Sharma, Hemant Kumar ;

Riadi, Yassine ;

Hassan, Md Quamrul .

MOLECULES, 2021, 26 (08)

[4] Chemical Evolution of Autotaxin Inhibitors [J].

Albers, Harald M. H. G. ;

Ovaa, Huib .

CHEMICAL REVIEWS, 2012, 112 (05) :2593-2603

[5] Discovery and Optimization of Boronic Acid Based Inhibitors of Autotaxin [J].

Albers, Harald M. H. G. ;

van Meeteren, Laurens A. ;

Egan, David A. ;

van Tilburg, Erica W. ;

Moolenaar, Wouter H. ;

Ovaa, Huib .

JOURNAL OF MEDICINAL CHEMISTRY, 2010, 53 (13) :4958-4967

[6] Boronic acid-based inhibitor of autotaxin reveals rapid turnover of LPA in the circulation [J].

Albers, Harald M. H. G. ;

Dong, Anping ;

van Meeteren, Laurens A. ;

Egan, David A. ;

Sunkara, Manjula ;

van Tilburg, Erica W. ;

Schuurman, Karianne ;

van Tellingen, Olaf ;

Morris, Andrew J. ;

Smyth, Susan S. ;

Moolenaar, Wouter H. ;

Ovaa, Huib .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2010, 107 (16) :7257-7262

[7]

Asal Fathia, 2021, Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry, V20, P302, DOI [10.2174/1871523020666210114092924, 10.2174/1871523020666210114092924]

[8] Selective Inhibition of Autotaxin Is Efficacious in Mouse Models of Liver Fibrosis [J].

Bain, Gretchen ;

Shannon, Kristen E. ;

Huang, Fei ;

Darlington, Janice ;

Goulet, Lance ;

Prodanovich, Patricia ;

Ma, Gina L. ;

Santini, Angelina M. ;

Stein, Adam J. ;

Lonergan, Dave ;

King, Christopher D. ;

Calderon, Imelda ;

Lai, Andiliy ;

Hutchinson, John H. ;

Evans, Jilly F. .

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2017, 360 (01) :1-13

[9] Discovery and optimization of ATX inhibitors via modeling, synthesis and biological evaluation [J].

Balupuri, Anand ;

Lee, Myeong Hwi ;

Chae, Sangeun ;

Jung, Eunmi ;

Yoon, Woosub ;

Kim, Yunki ;

Son, So Jung ;

Ryu, Jeonghee ;

Kang, Dae-Hyuck ;

Yang, Young-Jae ;

You, Ji-Na ;

Kwon, Hyunjin ;

Jeong, Jong-Woo ;

Koo, Tae-Sung ;

Lee, Dae-Yon ;

Kang, Nam Sook .

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 148 :397-409

[10] Design, synthesis, docking and biological evaluation of 4-phenyl-thiazole derivatives as autotaxin (ATX) inhibitors [J].

Balupuri, Anand ;

Lee, Dae-Yon ;

Lee, Myeong Hwi ;

Chae, Sangeun ;

Jung, Eunmi ;

Kim, Yunki ;

Ryu, Jeonghee ;

Kang, Nam Sook .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2017, 27 (17) :4156-4164

← 1 2 3 4 5 6 →