The effect of CX3CL1/CX3CR1 signal axis on microglia in central nervous system diseases

被引：13

作者：

Zhao, Jianhua ^{[1
]}

Li, Qiong ^{[1
]}

Ouyang, Xiantao ^{[2
]}

Wang, Fan ^{[1
]}

Li, Qing ^{[1
]}

Xu, Zhixiu ^{[1
]}

Ji, Danxia ^{[1
]}

Wu, Qingwu ^{[3
]}

Zhang, Jian ^{[3
]}

Lu, Chengbiao ^{[4
]}

Ji, Sibei ^{[1
]}

Li, Shaomin ^{[5
]}

机构：

[1] Xinxiang Med Univ, Affiliated Hosp 1, Henan Joint Int Res Lab Neurorestoratol Senile Dem, Henan Key Lab Neurorestoratol,Neurol, Weihui 453100, Henan, Peoples R China

[2] Xinxiang Med Univ, Management Coll, Xinxiang 45003, Henan, Peoples R China

[3] Xinxiang Med Univ, Affiliated Hosp 1, Imaging Dept, Weihui 453100, Henan, Peoples R China

[4] Xinxiang Med Univ, Dept Physiol & Neurobiol, Sino UK Joint Lab Brain Funct & Injury Henan Prov, Xinxiang 453003, Henan, Peoples R China

[5] Harvard Med Sch, Brigham & Womens Hosp, Ann Romney Ctr Neurol Dis, Boston, MA 02115 USA

来源：

JOURNAL OF NEURORESTORATOLOGY | 2023年 / 11卷 / 01期

关键词：

CX3CL1; CX3CR1; Cognitive function; Microglia; Central nervous system; Neuroprotection; WHITE-MATTER; FRACTALKINE; INJURY; CX3CR1; ACCUMULATION; INFLAMMATION; MODULATION; ACTIVATION; MECHANISMS; SYNAPSES;

D O I：

10.1016/j.jnrt.2023.100042

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

CX3C chemokine ligand 1 (CX3CL1), a unique member of the CX3C family, is most widely expressed in endothelial cells and neurons. Its specific receptor is CX3CR1, which is mainly expressed in central nervous system (CNS) microglia. CX3CL1 has effects on the brain and neurological system. CX3CL1 and its specific receptor CX3CR1 can inhibit calcium influx in neurons, promote the activation of protein kinases and the activation of nuclear transcription factor kB, etc., thereby reducing the release of inflammatory factors and achieving small stable glue in the state of plasmocytes and inhibiting the inflammatory response in CNS. This phenomenon limits neuronal death to a certain extent and has a particular neu-roprotective effect. Currently, the CX3CL1/CX3CR1 signal axis impact is of particular interest in a variety of CNS disorders, such as Alzheimer's disease, stroke, cerebral small vessel disease, Parkinson's disease, epilepsy, and other diseases. A wealth of studies has reported CX3CL1/CX3CR1 signal axis as a functional regulator of microglia, thereby affecting the occurrence and development of CNS diseases. The current article briefly enlightens the role of the CX3CL1/CX3CR1 signal axis and microglia and its effect on CNS diseases.(c) 2023 The Authors. Published by Elsevier Ltd on behalf of Tsinghua University Press. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

引用

页数：5

共 49 条

[11] Fractalkine and CX3CR1 mediate a novel mechanism of leukocyte capture, firm adhesion, and activation under physiologic flow [J].