Iron-Catalyzed Synthesis of Peroxylpyrrolo[2,1-a]isoquinolines through Oxidative Dearomatization

被引：4

作者：

Huang, Xiang ^{[1
,2
]}

Yu, An-Ni ^{[1
]}

Yang, De ^{[1
]}

Gao, Xin ^{[1
]}

Liang, Shu-Ting ^{[1
]}

Pei, Shu-Chen ^{[2
]}

Cui, Hai-Lei ^{[1
]}

机构：

[1] Chongqing Univ Arts & Sci, Coll Chem & Environm Engn, Chongqing 402160, Peoples R China

[2] Chongqing Univ Sci & Technol, Sch Chem & Chem Engn, Chongqing 401331, Peoples R China

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2023年 / 88卷 / 21期

基金：

中国国家自然科学基金;

关键词：

ALPHA; BETA-UNSATURATED KETONES; ENANTIOSELECTIVE PEROXIDATION; ARTEMISININ; ALKALOIDS; QINGHAOSU;

D O I：

10.1021/acs.joc.3c01824

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A mild late-stage modification of pyrrolo-[2,1-a]-isoquinolines was established through iron-catalyzed oxidative dearomatization and peroxidation. Peroxylated pyrroloisoquinolines have been prepared readily with hydroperoxide in low to good yields (up to 72%) at room temperature. Interestingly, the treatment of fully aromatized pyrrolo-[1,2-a]-quinolines under the current reaction system resulted in the formation of ring-opening products.

引用

页码：15326 / 15334

页数：9

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