Synthesis of New Fused Pyrano[4,3-b]pyridines from Ethyl 3-Aminopyrano[4,3-b]thieno[3,2-e]pyridine-2-carboxylate

被引：2

作者：

Dabayeva, V. V. ^{[1
]}

Baghdasaryan, M. R. ^{[1
]}

Paronikyan, E. G. ^{[1
]}

Barkhudaryants, I. M. ^{[1
]}

Panosyan, H. A. ^{[1
]}

Stepanyan, H. M. ^{[1
]}

Dashyan, Sh. Sh. ^{[1
]}

机构：

[1] Natl Acad Sci Armenia, Sci Technol Ctr Organ & Pharmaceut Chem, Yerevan 0014, Armenia

来源：

RUSSIAN JOURNAL OF ORGANIC CHEMISTRY | 2023年 / 59卷 / 01期

关键词：

pyrano[4,3-b]pyridine; pyrano[4,3-b]thieno[3,2-e]pyridine; pyrano[3?,4?:5',6']pyrido[3',2':4,5]-thieno[3,2-d]pyrimidine,; ntibacterial activity;

D O I：

10.1134/S1070428023010086

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Methods have been developed for the synthesis of novel fused pyrano[4,3-b]pyridine derivatives from ethyl 3-amino-4-(furan-2-yl)-7,7-dimethyl-7,8-dihydro-5H-pyrano[4,3-b]thieno[3,2-e]pyridine-2-carbox-ylate. Reactions of its 3-(phenoxycarbonyl)amino derivative with primary and secondary amines have been studied. The reactions with primary amine were accompanied by cyclization with the formation of fused pyrimidines. In the reactions with secondary amines, the product structure depended on the conditions. The synthesized compounds showed a weak antibacterial activity.

引用

页码：78 / 84

页数：7

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