Prognostic Impact of Sarcopenia in Patients with Advanced Prostate Carcinoma: A Systematic Review

被引:7
|
作者
De Pablos-Rodriguez, Pedro [1 ,2 ]
Del Pino-Sedeno, Tasmania [3 ,4 ,5 ]
Infante-Ventura, Diego [3 ,4 ]
De Armas-Castellano, Aythami [3 ,4 ]
Ramirez Backhaus, Miguel [1 ]
Loro Ferrer, Juan Francisco [6 ]
De Pablos-Velasco, Pedro [7 ,8 ]
Rueda-Dominguez, Antonio [5 ,9 ,10 ]
Trujillo-Martin, Maria M. [3 ,4 ,5 ,10 ]
机构
[1] Inst Valenciano Oncol IVO, Dept Urol, Valencia 46009, Spain
[2] Univ Las Palmas de Gran Canaria ULPGC, Doctoral Sch, Las Palmas Gran Canaria 35001, Spain
[3] Canary Isl Hlth Res Inst Fdn FIISC, Santa Cruz De Tenerife 38320, Spain
[4] Canary Isl Hlth Serv SESCS, Evaluat Unit, Santa Cruz De Tenerife 38109, Spain
[5] Network Res Chron Primary Care & Hlth Promot RICA, Santa Cruz De Tenerife 38109, Spain
[6] Univ Las Palmas de Gran Canaria ULPGC, Dept Clin Sci, Las Palmas Gran Canaria 35001, Spain
[7] Univ Hosp Gran Canaria Doctor Negrin, Dept Endocrinol & Nutr, Las Palmas Gran Canaria 35012, Spain
[8] Univ Las Palmas De Gran Canaria ULPGC, Res Inst Biomed & Hlth Sci IUIBS, Las Palmas Gran Canaria 35001, Spain
[9] Reg & Virgen de la Victoria Univ Hosp, Med Oncol Interctr Unit, IBIMA, Malaga 29590, Spain
[10] Carlos III Hlth Inst, Res Network Hlth Serv Chron Dis REDISSEC, Madrid 28029, Spain
关键词
prostatic neoplasms; sarcopenia; prognosis; survival; systematic review; meta-analysis; ANDROGEN-DEPRIVATION; BODY-COMPOSITION; CANCER PATIENTS; INTERMITTENT; CHEMOTHERAPY; MONOTHERAPY; DENSITY;
D O I
10.3390/jcm12010057
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Prostate cancer (PCa) is the second most common cancer in men and the fifth leading cause of death from cancer. The possibility of sarcopenia being a prognostic factor in advanced PCa patients has recently become a subject of interest. The aim of the present study was to evaluate the prognostic value of sarcopenia in advanced prostate carcinoma. A systematic review was conducted in Medline, EMBASE, and Web of Science (March, 2021). The quality of studies was assessed using the Quality in Prognosis Studies tool. Meta-analyses for overall, cancer-specific, and progression-free survival were performed. Nine studies (n = 1659) were included. Sarcopenia was borderline associated with a shorter overall survival (HR = 1.20, 95% CI: 1.01, 1.44, P = 0.04, I-2 = 43%) but was significantly associated with progression-free survival (HR = 1.61, 95% CI: 1.26, 2.06, P < 0.01; k = 3; n = 588). Available evidence supports sarcopenia as an important prognostic factor of progression-free survival in patients with advanced PCa. However, sarcopenia has a weak association with a shorter overall survival. The evidence on the role of sarcopenia in prostate-cancer-specific survival is insufficient and supports the need for further research. Patient summary: The literature was reviewed to determine whether the loss of muscle mass (sarcopenia) affects the survival in patients with advanced PCa. Patients with advanced PCa and sarcopenia were found to have a shorter progression-free survival (the length of time during and after treatment of a cancer that the patient lives with the disease but it does not get worse), but sarcopenia did not have much influence on the overall survival and cancer-specific survival (the length of time from either the date of diagnosis or the start of treatment to the date of death due to the cancer).
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页数:15
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