An Evidence-Based Approach to Orthobiologics for Tendon Disorders

被引：0

作者：

Abadin, Andre Armando ^{[1
]}

Orr, Jordan Pearl ^{[1
]}

Lloyd, Alexander Raphael ^{[1
]}

Henning, Phillip Troy ^{[1
]}

Pourcho, Adam ^{[2
]}

机构：

[1] Swedish Med Ctr, Dept Sports Spine & Musculoskeletal Med, 1600 E Jefferson St,Suite 300, Seattle, WA 98122 USA

[2] Elite Sports Performance Med, 11545 15th Ave Northeast,Suite 105, Seattle, WA 98125 USA

来源：

PHYSICAL MEDICINE AND REHABILITATION CLINICS OF NORTH AMERICA | 2023年 / 34卷 / 01期

关键词：

Tendinopathy; Tendinosis; Orthobiologics; Platelet-rich plasma (PRP; Mesenchymal signal cells; PLATELET-RICH PLASMA; MESENCHYMAL STEM-CELLS; RANDOMIZED CONTROLLED-TRIAL; MIDPORTION ACHILLES TENDINOPATHY; HIGH HAMSTRING TENDINOPATHY; AUTOLOGOUS WHOLE-BLOOD; ROTATOR CUFF REPAIR; QUALITY-OF-LIFE; DOUBLE-BLIND; MEDIAL EPICONDYLITIS;

D O I：

10.1016/j.pmr.2022.08.007

中图分类号：

R49 [康复医学];

学科分类号：

100215 ;

摘要：

Many studies have outlined the safety and effectiveness of orthobiologics for the treatment of tendinopathies; however, ample evidence is still lacking to consider these interventions to be standard of care. The most compelling data are for the treatment of CET and PF. PRP and MSCs should be considered in refractory cases of tendinopathy after exhausting conservative measures or could be considered as an adjunct for pain reduction, whereas a patient is undergoing conservative management. Future RCTs, preferably with investigational new drug approval, with long-term follow-up, are imperative to determine the ideal treatment protocol (ie, formulation, number and frequency of injections), type of orthobiologic, and patient characteristics.

引用

页码：83 / 103

页数：21

共 123 条

[1] Magnetic resonance and ultrasound in achilles tendinopathy: Predictive role and response assessment to platelet-rich plasma and adipose-derived stromal vascular fraction injection [J].