Endoscopically guided interventional photodynamic therapy for orthotopic pancreatic ductal adenocarcinoma based on NIR-II fluorescent nanoparticles

被引：8

作者：

Chen, Kang ^{[1
,4
,5
]}

Yin, Baoli ^{[2
]}

Luo, Quanneng ^{[1
,4
]}

Liu, Yi ^{[1
,4
]}

Wang, Yi ^{[1
,4
]}

Liao, Yan ^{[1
,4
]}

Li, Yuhang ^{[1
,4
]}

Chen, Xu ^{[1
,4
]}

Sun, Bo ^{[1
,4
]}

Zhou, Ning ^{[1
,4
]}

Liu, Hongwen ^{[1
,4
]}

Peng, Chuang ^{[1
]}

Liu, Sulai ^{[1
,5
]}

Cheng, Wei ^{[1
,3
,4
]}

Song, Guosheng ^{[2
]}

机构：

[1] Hunan Normal Univ, Dept Hepatobiliary Surg, Hunan Prov Peoples Hosp, Affiliated Hosp 1, Changsha 410005, Peoples R China

[2] Hunan Univ, Coll Chem & Chem Engn, State Key Lab Chemo Bio Sensing & Chemometr, Changsha 410082, Peoples R China

[3] Xiangyue Hosp, Hunan Inst Parasit Dis, Natl Clin Ctr Schistosomiasis Treatment, Yueyang 414000, Peoples R China

[4] Hunan Normal Univ, Translat Med Lab Pancreas Dis, Changsha 410005, Peoples R China

[5] Hunan Normal Univ, Cent Lab, Hunan Prov Peoples Hosp, Affiliated Hosp 1, Changsha 410005, Peoples R China

来源：

THERANOSTICS | 2023年 / 13卷 / 13期

基金：

中国国家自然科学基金;

关键词：

Endoscopy; NIR-II; Photodynamic therapy; Pancreatic cancer; CANCER;

D O I：

10.7150/thno.84164

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Rationale: Pancreatic cancer, comprising mostly pancreatic ductal adenocarcinoma (PDAC), is a highly malignant disease, typically known as a hypoxic tumor microenvironment. The application of PDT in pancreatic cancer in clinic is still hampered by several shortcomings, including the (i) deep location of pancreatic cancer, (ii) tissue damage induced by optical fibers, (iii) hypoxic microenvironment, (iv) short excitation wavelengths of traditional photosensitizers, and (v) poor delivery efficiency of photosensitizers. Methods: We designed an organic nanoparticle as photosensitizer for near-infrared II (NIR-II) fluorescent (FL) imaging that exerts a type I PDT effect on deep orthotopic pancreatic tumors under excitation by a NIR (808 nm) laser. Results: This novel photosensitizer exhibits enhanced accumulation in orthotopic pancreatic cancer in mice and could be used to effectively detect pancreatic cancer and guide subsequent laser irradiation for accurate PDT of deep pancreatic cancer. In addition, we built an endoscopic platform monitored by NIR-II FL imaging to achieve minimally invasive endoscopically guided interventional photodynamic therapy (EG-iPDT) with efficient inhibition of orthotopic pancreatic cancer, which prolonged overall survival up to 78 days compared to PBS + EG-iPDT group (*p < 0.05) in a mouse model. Conclusions: Minimally invasive EG-iPDT has promise as an intraoperative treatment for early-stage or unresectable or metastatic pancreatic cancer.

引用

页码：4469 / 4481

页数：13

共 27 条

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