Association of marine PUFAs intakes with cardiovascular disease, all-cause mortality, and cardiovascular mortality in American adult male patients with dyslipidemia: the US National Health and Nutrition Examination Survey, 2001 to 2016

被引：8

作者：

Tang, Xuanfeng ^{[1
]}

Lv, Xinyi ^{[1
]}

Wang, Ruohua ^{[1
]}

Li, Xiaoqing ^{[1
]}

Xu, Wenyu ^{[1
]}

Wang, Nan ^{[1
]}

Ma, Shuran ^{[1
]}

Huang, He ^{[1
]}

Niu, Yucun ^{[1
]}

Kong, Xiangju ^{[2
]}

机构：

[1] Harbin Med Univ, Sch Publ Hlth, Dept Nutr & Food Hyg, Key Lab Precis Nutr & Hlth, Harbin, Peoples R China

[2] Harbin Med Univ, Dept Gynaecol, Affiliated Hosp 1, Harbin, Peoples R China

来源：

NUTRITION JOURNAL | 2023年 / 22卷 / 01期

基金：

中国国家自然科学基金;

关键词：

Dyslipidemia; Mortality; Marine PUFAs; CVD; NHANES; RISK-FACTORS; PROFILES; DPA; EPA; DHA;

D O I：

10.1186/s12937-023-00873-6

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

BackgroundThe relationship between marine polyunsaturated fatty acid (PUFA) intake and cardiovascular disease and mortality in dyslipidemic patients is unclear. Men with dyslipidemia have a higher risk of cardiovascular disease than women, and PUFA supplementation may be more beneficial in men.ObjectiveThe purpose of this study was to assess the relationship between different types of marine polyunsaturated fatty acids intakes and cardiovascular disease, all-cause mortality, and cardiovascular mortality in adult U.S. males with dyslipidemia.MethodsThe study ultimately included 11,848 adult men with dyslipidemia who were screened from the National Health and Nutrition Examination Survey (NHANES) between 2001 and 2016. This was linked to the 2019 National Death Index (NDI) records to establish a prospective cohort. In the study, a logistic regression model was established to assess the relationship between PUFA intake and prevalent CVD, and a Cox proportional hazards regression model was established to assess the relationship between PUFA intake and death.ResultsIn the fully adjusted models, compared with participants in the lowest tertile, participants with the highest DPA intake were associated with a lower risk of CVD (CVD: OR = 0.71, 95%CI: 0.55, 0.91; angina: OR = 0.54, 95%CI: 0.38, 0.79; stroke: OR = 0.62, 95%CI: 0.43, 0.89), but not with three subtypes of congestive heart failure, coronary heart disease, and myocardial infarction. And the highest tertile level of DPA intake can reduce all-cause mortality (HR = 0.77, 95%CI: 0.64, 0.91) and CVD mortality (HR = 0.68, 95%CI: 0.52, 0.90).ConclusionsCardiovascular disease risk, all-cause mortality, and CVD mortality were inversely associated with dietary DPA intake but not EPA and DHA intakes in U.S. male participants with dyslipidemia.

引用

页数：12

共 37 条

[1]

Akiba S, 2000, BIOL PHARM BULL, V23, P1293, DOI 10.1248/bpb.23.1293

[2]

[Anonymous], NAT HLTH NUTR EX SUR

[3] Innate immune memory in cardiometabolic disease [J].