Onychomycosis: Old and New

被引：33
作者：
Bermudez, Narges Maskan [1 ]
Rodriguez-Tamez, Giselle [2 ]
Perez, Sofia [1 ]
Tosti, Antonella [1 ]
机构：
[1] Univ Miami, Miller Sch Med, Dr Philip Frost Dept Dermatol & Cutaneous Surg, Miami, FL 33125 USA
[2] Univ Autonoma Nuevo Leon, Univ Hosp Dr Jose Eleuterio Gonzalez, Dermatol Dept, Monterrey 64460, Mexico
来源：
JOURNAL OF FUNGI | 2023年 / 9卷 / 05期
关键词：
onychomycosis; dermatophyte; dermoscopy; fungal culture; fungal nail infection; nondermatophyte; yeast; DERMATOPHYTE TOENAIL ONYCHOMYCOSIS; DOUBLE-BLIND; CONTINUOUS TERBINAFINE; NAIL LACQUER; INTERMITTENT ITRACONAZOLE; UNSUSPECTED ONYCHOMYCOSIS; SUBUNGUAL ONYCHOMYCOSIS; PARALLEL-GROUP; SINGLE-BLIND; RISK-FACTORS;
D O I：
10.3390/jof9050559
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Onychomycosis is a common chronic fungal infection of the nail that causes discoloration and/or thickening of the nail plate. Oral agents are generally preferred, except in the case of mild toenail infection limited to the distal nail plate. Terbinafine and itraconazole are the only approved oral therapies, and fluconazole is commonly utilized off-label. Cure rates with these therapies are limited, and resistance to terbinafine is starting to develop worldwide. In this review, we aim to review current oral treatment options for onychomycosis, as well as novel oral drugs that may have promising results in the treatment of onychomycosis.
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页数：13
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共 103 条
[21]   CLINICAL PEARL - DIAGNOSIS OF ONYCHOMYCOSIS [J].
ELEWSKI, BE .
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 1995, 32 (03) :500-501
[22]   Large-scale epidemiological study of the causal agents of onychomycosis: Mycological findings from the multicenter onychomycosis study of terbinafine [J].
Elewski, BE .
ARCHIVES OF DERMATOLOGY, 1997, 133 (10) :1317-1318
[23]   Efinaconazole 10% solution in the treatment of toenail onychomycosis: Two phase III multicenter, randomized, double-blind studies [J].
Elewski, Boni E. ;
Rich, Phoebe ;
Pollak, Richard ;
Pariser, David M. ;
Watanabe, Shinichi ;
Senda, Hisato ;
Ieda, Chikara ;
Smith, Kathleen ;
Pillai, Radhakrishnan ;
Ramakrishna, Tage ;
Olin, Jason T. .
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 2013, 68 (04) :600-608
[24]   How often does oral treatment of toenail onychomycosis produce a disease-free nail? An analysis of published data [J].
Epstein, E .
ARCHIVES OF DERMATOLOGY, 1998, 134 (12) :1551-1554
[25]   Double blind, randomised study of continuous terbinafine compared with intermittent itraconazole in treatment of toenail onychomycosis [J].
Evans, EGV ;
Sigurgeirsson, B .
BMJ-BRITISH MEDICAL JOURNAL, 1999, 318 (7190) :1031-1035
[26]   Oral antifungal therapies for toenail onychomycosis: a systematic review with network meta-analysis toenail mycosis: network meta-analysis [J].
Favero, Maria L. D. ;
Bonetti, Aline F. ;
Domingos, Eric L. ;
Tonin, Fernanda S. ;
Pontarolo, Roberto .
JOURNAL OF DERMATOLOGICAL TREATMENT, 2022, 33 (01) :121-130
[27]   A large-scale North American study of fungal isolates from nails: The frequency of onychomycosis, fungal distribution, and antifungal susceptibility patterns [J].
Ghannoum, MA ;
Hajjeh, RA ;
Scher, R ;
Konnikov, N ;
Gupta, AK ;
Summerbell, R ;
Sullivan, S ;
Daniel, R ;
Krusinski, P ;
Fleckman, P ;
Rich, P ;
Odom, R ;
Aly, R ;
Pariser, D ;
Zaiac, M ;
Rebell, G ;
Lesher, J ;
Gerlach, B ;
Ponce-de-Leon, GF ;
Ghannoum, A ;
Warner, J ;
Isham, N ;
Elewski, B .
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 2000, 43 (04) :641-648
[28]   Prevalence and risk factors of onychomycosis in primary school children living in rural and urban areas in Central Anatolia of Turkey [J].
Gulgun, Mustafa ;
Balci, Elcin ;
Karaoglu, Abdulbaki ;
Kesik, Vural ;
Babacan, Oguzhan ;
Fidanci, Muzaffer Kursat ;
Turker, Turker ;
Tok, Duran ;
Koc, Nedret .
INDIAN JOURNAL OF DERMATOLOGY VENEREOLOGY & LEPROLOGY, 2013, 79 (06) :777-782
[29]   The efficacy and safety of pulse vs. continuous therapy for dermatophyte toenail onychomycosis [J].
Gupta, A. K. ;
Stec, N. ;
Bamimore, M. A. ;
Foley, K. A. ;
Shear, N. H. ;
Piguet, V. .
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY, 2020, 34 (03) :580-588
[30]   A critical review of improvement rates for laser therapy used to treat toenail onychomycosis [J].
Gupta, A. K. ;
Versteeg, S. G. .
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY, 2017, 31 (07) :1111-1118
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