A sustainable metal and base-free direct amidation of esters using water as a green solvent

被引：1

作者：

Rajendran, Nanthini ^{[1
]}

Kamaraj, Kiruthigadevi ^{[1
]}

Janakiraman, Saranya ^{[1
]}

Saral, Mary ^{[1
]}

Dixneuf, Pierre H. ^{[2
]}

Bheeter, Charles Beromeo ^{[1
]}

机构：

[1] Vellore Inst Technol, Sch Adv Sci, Dept Chem, Vellore 632014, Tamil Nadu, India

[2] Univ Rennes, ISCR, UMR CNRS 6226, F-35000 Rennes, France

来源：

RSC ADVANCES | 2023年 / 13卷 / 22期

关键词：

CATALYZED DIRECT AMIDATION; AMIDE BOND FORMATION; MILD; TRANSAMIDATION; PRECATALYST; CONVERSION; REAGENTS; LACTONES; CLEAVAGE;

D O I：

10.1039/d3ra02637j

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Herein, we report a simple and efficient synthetic approach for direct amidation of esters via C(acyl)-O bond cleavage without any additional reagents or catalysts, using only water as a green solvent. Subsequently, the reaction byproduct is recovered and utilized for the next phase of ester synthesis. This method emphasized metal-free, additive-free, and base-free characteristics making it a new, sustainable, and eco-friendly way to realize direct amide bond formation. In addition, the synthesis of the drug molecule diethyltoluamide and the Gram-scale synthesis of a representative amide are demonstrated.

引用

页码：14958 / 14962

页数：5

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