Introducing Savie: A Biodegradable Surfactant Enabling Chemo-and Biocatalysis and Related Reactions in Recyclable Water

被引：49

作者：

Kincaid, Joseph R. A. ^{[1
]}

Wong, Madison J. ^{[1
]}

Akporji, Nnamdi ^{[1
]}

Gallou, Fabrice ^{[2
]}

Fialho, David M. ^{[1
]}

Lipshutz, Bruce H. ^{[1
]}

机构：

[1] Univ Calif Santa Barbara, Dept Chem & Biochem, Santa Barbara, CA 93106 USA

[2] Novartis Pharm AG, CH-4057 Basel, Switzerland

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2023年 / 145卷 / 07期

关键词：

MIYAURA CROSS-COUPLINGS; POLYETHYLENE-GLYCOL; GREEN CHEMISTRY; CATALYSIS; NANOPARTICLES; METAL; MILD; POLYPEPTIDES; SUBSTITUTION; MODULATION;

D O I：

10.1021/jacs.2c13444

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Savie is a biodegradable surfactant derived from vitamin E and polysarcosine (PSar) developed for use in organic synthesis in recyclable water. This includes homogeneous catalysis (including examples employing only ppm levels of catalyst), heterogeneous catalysis, and biocatalytic transformations, including a multistep chemoenzymatic sequence. Use of Savie frequently leads to significantly higher yields than do conventional surfactants, while obviating the need for wastegenerating organic solvents. [GRAPHICS]

引用

页码：4266 / 4278

页数：13

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