Palladium-Catalyzed Aminations in Flow ... on Water

被引：3
|
作者：
Wong, Madison J. [1 ]
Oftadeh, Erfan [1 ]
Saunders, John M. [1 ]
Wood, Alex B. [1 ]
Lipshutz, Bruce H. [1 ]
机构：
[1] Univ Calif Santa Barbara, Dept Chem & Biochem, Santa Barbara, CA 93106 USA
来源：
ACS CATALYSIS | 2024年 / 14卷 / 03期
关键词：
aminations; flow chemistry; plug flow; C-N bond formation; palladium catalysis; BUCHWALD-HARTWIG AMINATION; GREEN CHEMISTRY; COMPLEXES; CHLORIDES; REACTOR;
D O I：
10.1021/acscatal.3c05257
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
Aminations can be efficiently run, under plug flow conditions on water, catalyzed by low levels of a recyclable palladium precatalyst. General protocols to couple amines, both aryl and aliphatic, with aryl/heteroaryl bromides have been developed. Further highlights include "on water" conditions, short reaction times, recycling of the reaction medium, low levels of residual Pd in the isolated products, and low E factors as a green metric, all of these features showcasing this alternative to amination reactions typically run in batch mode.
引用
收藏
页码：1545 / 1552
页数：8
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