A protocol for creating endometriosis in rhesus macaques (Macaca mulatta)

被引:2
作者
Slayden, Ov D. [1 ,2 ,4 ]
Luo, Fangzhou [1 ]
Martin, Lauren D. [3 ]
机构
[1] Oregon Natl Primate Res Ctr, Div Reprod & Dev Sci, Beaverton, OR USA
[2] Oregon Hlth & Sci Univ, Dept Obstet & Gynecol, Portland, OR USA
[3] Oregon Natl Primate Res Ctr, Div Anim Resources & Res Support, Beaverton, OR USA
[4] Oregon Natl Primate Res Ctr, Div Reprod & Dev Sci, 505 NW 185th Ave, Beaverton, OR 97006 USA
关键词
animal model; endometriosis; laparoscopic surgery; menstruation; rhesus macaque; BABOON MODEL; PROGESTERONE RESISTANCE; ESTROGEN-RECEPTOR; LESIONS; TISSUE; PATHOPHYSIOLOGY; PATHOGENESIS; ADENOMYOSIS; MACROPHAGES; THERAPIES;
D O I
10.1111/jmp.12681
中图分类号
S85 [动物医学(兽医学)];
学科分类号
0906 ;
摘要
Background Endometriosis is the presence of endometrium-like tissue outside the uterine cavity. An experimental model of endometriosis has been created in the baboon by the transcervical collection and laparoscopic inoculation of menstrual endometrium. Macaques are the preferred model for pharmaceutical development, but the complex anatomy of the macaque cervix makes the baboon method impractical. In this work, we sought to validate a surgical approach for creating endometriosis in macaques.Methods Menstrual endometrium was collected via laparoscopic intrauterine puncture and transferred to the peritoneal cavity. We repeated this procedure during three menstruations. Endometriotic tissue was identified during laparoscopy, collected, and characterized by immunohistochemistry.Results Sham surgery-treated animals (n = 3) failed to develop endometriosis. We identified red, powder burnt, and white lesions in 13/14 of the treated animals; the stroma of the red lesions stained positive for ovarian steroid receptors.Conclusion This surgical technique can reliably create hormone-responsive endometriosis in macaques for therapeutic studies.
引用
收藏
页码:405 / 413
页数:9
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