Both epilepsy and anti-seizure medications affect bone metabolism in children with self-limited epilepsy with centrotemporal spikes

被引：5

作者：

Shi, Xiu-Yu ^{[1
]}

Ju, Jun ^{[2
]}

Lu, Qian ^{[1
]}

Hu, Lin-Yan ^{[1
]}

Tian, Ya-Ping ^{[3
]}

Guo, Guang-Hong ^{[4
]}

Liu, Zhi-Sheng ^{[5
]}

Wu, Ge-Fei ^{[5
]}

Zhu, Hong-Min ^{[5
]}

Zhang, Yu-Qin ^{[6
]}

Li, Dong ^{[6
]}

Gao, Li ^{[7
]}

Yang, Liu ^{[7
]}

Wang, Chun-Yu ^{[8
]}

Liao, Jian-Xiang ^{[9
]}

Wang, Ji-Wen ^{[10
]}

Zhou, Shui-Zhen ^{[11
]}

Wang, Hua ^{[12
]}

Li, Xiao-Jing ^{[13
]}

Gao, Jing-Yun ^{[14
]}

Zhang, Li ^{[15
]}

Shu, Xiao-Mei ^{[16
]}

Li, Dan ^{[17
]}

Li, Yan ^{[18
]}

Chen, Chun-Hong ^{[19
]}

Zhang, Xiu-Ju ^{[20
]}

Zhong, Jian-Min ^{[21
]}

Zhai, Qiong-Xiang ^{[22
]}

Sun, Yan-Hong ^{[23
]}

Lin, Xue-Feng ^{[24
]}

Ren, Rong-Na ^{[25
]}

Yin, Fei ^{[26
]}

Chen, Yan-Hui ^{[27
]}

Jia, Fei-Yong ^{[28
]}

Yang, Zhi-Xian ^{[29
]}

Wang, Ju-Li ^{[30
]}

Xia, Zhe-Zhi ^{[31
]}

Wang, Li-Wen ^{[32
]}

Luo, Rong ^{[33
]}

Zou, Li-Ping ^{[1
,34
]}

机构：

[1] Chinese Peoples Liberat Army Gen Hosp, Med Ctr 1, Dept Pediat, Beijing 100853, Peoples R China

[2] Capital Med Univ, Beijing Chao Yang Hosp, Dept Pediat, Beijing, Peoples R China

[3] Chinese Peoples Liberat Army Gen Hosp, Res Ctr Birth Defect Prevent Technol, Med Innovat Res Div, Beijing, Peoples R China

[4] Chinese Peoples Liberat Army Gen Hosp, Med Ctr 1, Dept Lab Med, Beijing, Peoples R China

[5] Huazhong Univ Sci & Technol, Wuhan Childrens Hosp, Tongji Med Coll, Dept Neurol, Wuhan, Peoples R China

[6] Tianjin Univ, Tianjin Childrens Hosp, Dept Neurol, Childrens Hosp, Tianjin, Peoples R China

[7] Zhengzhou Univ, Henan Prov Peoples Hosp, Dept Pediat, Peoples Hosp, Zhengzhou, Peoples R China

[8] Harbin Childrens Hosp, Dept Neurol, Harbin, Peoples R China

[9] Shenzhen Childrens Hosp, Dept Neurol, Shenzhen, Peoples R China

[10] Shanghai Jiao Tong Univ, Shanghai Childrens Med Ctr, Dept Neurol, Sch Med, Shanghai, Peoples R China

[11] Fudan Univ, Dept Neurol, Childrens Hosp, Shanghai, Peoples R China

[12] China Med Univ, Dept Pediat Neurol, Shengjing Hosp, Shenyang, Peoples R China

[13] Guangzhou Women & Childrens Med Ctr, Dept Neurol, Guangzhou, Peoples R China

[14] Hebei Tangshan City Maternal & Child Hlth Care Hos, Dept Pediat Neurol, Tangshan, Peoples R China

[15] Linyi Peoples Hosp, Dept Pediat, Linyi, Peoples R China

[16] Zunyi Med Coll, Dept Pediat, Zunyi, Peoples R China

[17] Xi An Jiao Tong Univ, Dept Pediat, Affiliated Hosp 2, Xian, Peoples R China

[18] Soochow Univ, Dept Neurol, Childrens Hosp, Suzhou, Peoples R China

[19] Capital Med Univ, Beijing Childrens Hosp, Natl Ctr Childrens Hlth, Dept Neurol, Beijing, Peoples R China

[20] Xingtai Peoples Hosp, Dept Pediat, Xingtai, Peoples R China

[21] Jiangxi Prov Childrens Hosp, Dept Neurol, Nanchang, Peoples R China

[22] Guangdong Gen Hosp, Dept Pediat, Guangzhou, Peoples R China

[23] Cangzhou Cent Hosp, Dept Pediat, Cangzhou, Peoples R China

[24] Quanzhou Childrens Hosp, Dept Neurol, Quanzhou, Peoples R China

[25] 900 Hosp Joint Logist Team, Dept Pediat, Fuzhou, Peoples R China

[26] Cent South Univ, Xiangya Hosp, Dept Pediat, Changsha, Peoples R China

[27] Fujian Med Univ, Dept Pediat, Union Hosp, Fuzhou, Peoples R China

[28] First Hosp Jilin Univ, Dept Dev & Behav Pediat, Changchun, Peoples R China

[29] Peking Univ, Dept Neurol, Hosp 1, Beijing, Peoples R China

[30] Cent Hosp Jiamusi City, Dept Epilepsy, Jiamusi, Peoples R China

[31] Zhejiang Univ, Childrens Hosp, Dept Neurol, Sch Med, Hangzhou, Peoples R China

[32] Capital Inst Pediat, Dept Neurol, Beijing, Peoples R China

[33] Sichuan Univ, West China Univ Hosp 2, Dept Pediat, Chengdu, Peoples R China

[34] Capital Med Univ, Beijing Inst Brain Disorders, Ctr Brain Disorders Res, Beijing, Peoples R China

来源：

EPILEPSIA | 2023年 / 64卷 / 10期

基金：

中国国家自然科学基金;

关键词：

anti-seizure medications; bone metabolism; child; epilepsy; self-limited epilepsy with centrotemporal spikes; MINERAL DENSITY; TURNOVER; MARKERS; MASS;

D O I：

10.1111/epi.17733

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Objective:l Bone metabolism can be influenced by a range of factors. We selected children with self-limited epilepsy with centrotemporal spikes (SeLECTS) and lifestyles similar to those of healthy children to control for the confounding factors that may influence bone metabolism. We aimed to identify the specific effects of epilepsy and/or anti-seizure medications (ASMs) on bone metabolism.Methods: Patients with SeLECTS were divided into an untreated group and a monotherapy group, and the third group was a healthy control group. We determined the levels of various biochemical markers of bone metabolism, including procollagen type I nitrogenous propeptide (PINP), alkaline phosphatase (ALP), osteocalcin (OC), collagen type I cross-linked C-telopeptide (CTX), calcium, magnesium, phosphorus, parathyroid hormone (PTH), and vitamin D-3 (VD3).Results: A total of 1487 patients (from 19 centers) were diagnosed with SeLECTS; 1032 were analyzed, including 117 patients who did not receive any ASMs (untreated group), 643 patients who received only one ASM (monotherapy group), and 272 children in the healthy control group. Except for VD3, other bone metabolism of the three groups were different (p < .001). Bone metabolism was significantly lower in the untreated group than the healthy control group (p < .05). There were significant differences between the monotherapy and healthy control group in the level of many markers. However, when comparing the monotherapy and untreated groups, the results were different; oxcarbazepine, levetiracetam, and topiramate had no significant effect on bone metabolism. Phosphorus and magnesium were significantly lower in the valproic acid group than the untreated group (adjusted p < .05, Cliff's delta .282-.768). CTX was significantly higher in the lamotrigine group than in the untreated group (adjusted p = .012, Cliff's delta = .316).Significance: Epilepsy can affect many aspects of bone metabolism. After controlling epilepsy and other confounders that affect bone metabolism, we found that the effects of ASMs on bone metabolism differed. Oxcarbazepine, levetiracetam, and topiramate did not affect bone metabolism, and lamotrigine corrected some of the abnormal markers of bone metabolism in patients with epilepsy.

引用

页码：2667 / 2678

页数：12

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