Pyroptosis-related non-coding RNAs emerging players in atherosclerosis pathology

被引：4

作者：

Khojali, Weam M. A. ^{[1
,2
]}

Khalifa, Nasrin E. ^{[3
,4
]}

Alshammari, Farhan ^{[3
]}

Afsar, S. ^{[5
]}

Aboshouk, Nayla Ahmed Mohammed ^{[6
]}

Khalifa, Amna Abakar Suleiman ^{[6
]}

Enrera, Jerlyn Apatan ^{[6
]}

Elafandy, Nancy Mohammad ^{[6
]}

Abdalla, Randa Abdeen Husien ^{[6
]}

Ali, Omar Hafiz Haj ^{[6
]}

Syed, Rahamat Unissa ^{[3
]}

Nagaraju, Potnuri ^{[7
]}

机构：

[1] Univ Hail, Coll Pharm, Dept Pharmaceut Chem, Hail 81442, Saudi Arabia

[2] Omdurman Islamic Univ, Fac Pharm, Dept Pharmaceut Chem, Omdurman 14415, Sudan

[3] Univ Hail, Coll Pharm, Dept Pharmaceut, Hail 81442, Saudi Arabia

[4] Univ Khartoum, Fac Pharm, Dept Pharmaceut, Khartoum 11115, Sudan

[5] Sri Venkateswara Univ, Dept Virol, Tirupati 517502, Andhra Pradesh, India

[6] Univ Hail, Coll Appl Med Sci, Dept Clin Lab Sci, Hail 81442, Saudi Arabia

[7] Mandesh Inst Pharmaceut Sci & Res Ctr, Dept Pharmaceut, Mhaswad, Maharashtra, India

来源：

PATHOLOGY RESEARCH AND PRACTICE | 2024年 / 255卷

关键词：

Atherosclerosis; Pyroptosis; NcRNAs; Ox-LDL; MALAT1; CANCER; PATHWAY; ROLES; PATHOGENESIS; PROGRESSION; PROBIOTICS; MUSHROOM; EXTRACT; CELLS; STATE;

D O I：

10.1016/j.prp.2024.155219

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Globally, atherosclerosis a persistent inflammatory condition of the artery walls continues to be the primary cause of cardiovascular illness and death. The ncRNAs are important regulators of important signalling pathways that affect pyroptosis and the inflammatory environment in atherosclerotic plaques. Comprehending the complex interaction between pyroptosis and non-coding RNAs (ncRNAs) offers fresh perspectives on putative therapeutic targets for ameliorating cardiovascular problems linked to atherosclerosis. The discovery of particular noncoding RNA signatures linked to the advancement of atherosclerosis could lead to the creation of novel biomarkers for risk assessment and customised treatment approaches. A thorough investigation of the regulatory networks regulated by these non-coding RNAs has been made possible by the combination of cutting-edge molecular methods and bioinformatics tools. Studying pyroptosis-related ncRNAs in detail appears to be a promising way to advance our understanding of disease pathophysiology and develop focused therapeutic methods as we work to unravel the complex molecular tapestry of atherosclerosis. This review explores the emerging significance of non-coding RNAs (ncRNAs) in the regulation of pyroptosis and their consequential impact on atherosclerosis pathology.

引用

页数：9

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