First complete remission favours haploidentical haematopoietic stem cell transplantation with post-transplant cyclophosphamide over cord blood transplantation in acute lymphoblastic leukaemia

被引：1

作者：

Jo, Tomoyasu ^{[1
,2
]}

Ueda, Tomoaki ^{[3
]}

Akahoshi, Yu ^{[4
]}

Kondo, Tadakazu ^{[1
,5
]}

Uchida, Naoyuki ^{[6
]}

Tanaka, Masatsugu ^{[7
]}

Nakamae, Hirohisa ^{[8
]}

Doki, Noriko ^{[9
]}

Ota, Shuichi ^{[10
]}

Sawa, Masashi ^{[11
]}

Ohigashi, Hiroyuki ^{[12
]}

Maruyama, Yumiko ^{[13
]}

Takayama, Nobuyuki ^{[14
]}

Nishida, Tetsuya ^{[15
]}

Hiramoto, Nobuhiro ^{[5
]}

Katayama, Yuta ^{[16
,17
]}

Kanda, Yoshinobu ^{[18
]}

Ichinohe, Tatsuo ^{[19
]}

Atsuta, Yoshiko ^{[20
,21
]}

Arai, Yasuyuki ^{[1
,2
]}

机构：

[1] Kyoto Univ, Grad Sch Med, Dept Hematol & Oncol, Kyoto, Japan

[2] Kyoto Univ Hosp, Ctr Res & Applicat Cellular Therapy, 54 Shogoin Kawahara Cho,Sakyo Ku, Kyoto 6068507, Japan

[3] Osaka Univ, Grad Sch Med, Dept Hematol & Oncol, Suita, Japan

[4] Jichi Med Univ, Div Hematol, Saitama Med Ctr, Saitama, Japan

[5] Kobe City Med Ctr Gen Hosp, Dept Hematol, Kobe, Japan

[6] Federat Natl Publ Serv Personnel Mutual Aid Assoc, Dept Hematol, Tokyo, Japan

[7] Kanagawa Canc Ctr, Dept Hematol, Kanagawa, Japan

[8] Osaka Metropolitan Univ Hosp, Dept Hematol, Osaka, Japan

[9] Komagome Hosp, Tokyo Metropolitan Canc & Infect Dis Ctr, Hematol Div, Tokyo, Japan

[10] Sapporo Hokuyu Hosp, Dept Hematol, Sapporo, Japan

[11] Anjo Kosei Hosp, Dept Hematol & Oncol, Anjo, Japan

[12] Hokkaido Univ Hosp, Dept Hematol, Sapporo, Hokkaido, Japan

[13] Univ Tsukuba Hosp, Dept Hematol, Tsukuba, Japan

[14] Kyorin Univ Hosp, Dept Hematol, Mitaka, Japan

[15] Nagoya Daiichi Hosp, Japanese Red Cross Aichi Med Ctr, Dept Hematol, Nagoya, Japan

[16] Hiroshima Red Cross Hosp, Dept Hematol, Hiroshima, Japan

[17] Atom Bomb Survivors Hosp, Hiroshima, Japan

[18] Jichi Med Univ, Div Hematol, Shimotsuke, Tochigi, Japan

[19] Hiroshima Univ, Res Inst Radiat Biol & Med, Dept Hematol & Oncol, Hiroshima, Japan

[20] Japanese Data Ctr Hematopoiet Cell Transplantat, Nagoya, Japan

[21] Aichi Med Univ, Sch Med, Dept Registry Sci Transplant & Cellular Therapy, Nagakute, Japan

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 2024年 / 204卷 / 05期

关键词：

acute lymphoblastic leukaemia; HLA-haploidentical stem cell transplantation using post-transplant cyclophosphamide; umbilical cord blood; BONE-MARROW-TRANSPLANTATION; TRUMP DATA; SCRIPTS;

D O I：

10.1111/bjh.19372

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

To assess the benefits of HLA-haploidentical haematopoietic stem cell transplantation using post-transplant cyclophosphamide (PTCy-haplo) relative to those of umbilical cord blood (UCB) transplantation in acute lymphoblastic leukaemia (ALL), we analysed 1999 patients (PTCy-haplo, 330; UCB, 1669), using the nationwide Japanese registry. PTCy-haplo was associated with a significantly higher relapse rate, but lower non-relapse mortality, which results in overall survival and disease-free survival, comparable to those of UCB. Among patients in CR1, PTCy-haplo showed a significantly higher survival than UCB regardless of the CD34+ cell dose. Our findings provide valuable insights into the donor selection algorithm in allogeneic HSCT for adult patients with ALL.

引用

页码：1913 / 1919

页数：7

共 15 条

[11] Hematopoietic stem cell transplantation with unrelated cord blood or haploidentical donor grafts in adult patients with secondary acute myeloid leukemia, a comparative study from Eurocord and the ALWP EBMT
Ruggeri, Annalisa
Labopin, Myriam
Savani, Bipin
Paviglianiti, Annalisa
Blaise, Didier
Volt, Fernanda
Ciceri, Fabio
Bacigalupo, Andrea
Tischer, Johanna
Chevallier, Patrice
Koc, Yener
Cornelissen, Jan J.
Ehninger, Gerard
Sanz, Guillermo
Deconinck, Erick
Rocha, Vanderson
Baron, Frederic
Mohty, Mohamad
Gluckman, Eliane
Nagler, Arnon
[J]. BONE MARROW TRANSPLANTATION, 2019, 54 (12) : 1987 - 1994
[12] Comparable survival outcomes with haploidentical stem cell transplantation and cord blood transplantation
Sugita, Junichi
Atsuta, Yoshiko
Nakamae, Hirohisa
Maruyama, Yumiko
Ishiyama, Ken
Shiratori, Souichi
Fukuda, Takahiro
Kurata, Mio
Shingai, Naoki
Ozawa, Yukiyasu
Masuko, Masayoshi
Nagafuji, Koji
Uchida, Naoyuki
Tanaka, Masatsugu
Onizuka, Makoto
Kanda, Junya
Kimura, Takafumi
Ichinohe, Tatsuo
Teshima, Takanori
[J]. BONE MARROW TRANSPLANTATION, 2022, 57 (11) : 1681 - 1688
[13] Myeloablative and reduced-intensity conditioning in HLA-haploidentical peripheral blood stem cell transplantation using post-transplant cyclophosphamide
Sugita, Junichi
Kagaya, Yusuke
Miyamoto, Toshihiro
Shibasaki, Yasuhiko
Nagafuji, Koji
Ota, Shuichi
Furukawa, Tatsuo
Nara, Miho
Akashi, Koichi
Taniguchi, Shuichi
Harada, Mine
Matsuo, Keitaro
Teshima, Takanori
[J]. BONE MARROW TRANSPLANTATION, 2019, 54 (03) : 432 - 441
[14] Single Cord Blood Transplantation Versus HLA-Haploidentical-related Donor Transplantation Using Posttransplant Cyclophosphamide in Patients With Hematological Malignancies
Wada, Fumiya
Kanda, Junya
Yoshioka, Satoshi
Ishikawa, Takayuki
Akasaka, Takashi
Ueda, Yasunori
Hirata, Hirokazu
Arai, Yasuyuki
Yago, Kazuhiro
Anzai, Naoyuki
Watanabe, Mitsumasa
Ikeda, Takashi
Yonezawa, Akihito
Imada, Kazunori
Itoh, Mitsuru
Kitano, Toshiyuki
Takeoka, Tomoharu
Hishizawa, Masakatsu
Nohgawa, Masaharu
Arima, Nobuyoshi
Asagoe, Kousuke
Kondo, Tadakazu
Takaori-Kondo, Akifumi
[J]. TRANSPLANTATION, 2022, 106 (06) : 1279 - 1287
[15] Haploidentical vs sibling, unrelated, or cord blood hematopoietic cell transplantation for acute lymphoblastic leukemia
Wieduwilt, Matthew J.
Metheny, Leland
Zhang, Mei-Jie
Wang, Hai-Lin
Estrada-Merly, Noel
Marks, David, I
Al-Homsi, A. Samer
Muffly, Lori
Chao, Nelson
Rizzieri, David
Gale, Robert Peter
Gadalla, Shahinaz M.
Cairo, Mitchell
Mussetti, Alberto
Gore, Steven
Bhatt, Vijaya Raj
Patel, Sagar S.
Michelis, Fotios, V
Inamoto, Yoshihiro
Badawy, Sherif M.
Copelan, Edward
Palmisiano, Neil
Kharfan-Dabaja, Mohamed A.
Lazarus, Hillard M.
Ganguly, Siddhartha
Bredeson, Christopher
Diaz Perez, Miguel Angel
Cassaday, Ryan
Savani, Bipin N.
Ballen, Karen
Martino, Rodrigo
Wirk, Baldeep
Bacher, Ulrike
Aljurf, Mahmoud
Bashey, Asad
Murthy, Hemant S.
Yared, Jean A.
Aldoss, Ibrahim
Farhadfar, Nosha
Liu, Hongtao
Abdel-Azim, Hisham
Waller, Edmund K.
Solh, Melhem
Seftel, Matthew D.
van der Poel, Marjolein
Grunwald, Michael R.
Liesveld, Jane L.
Kamble, Rammurti T.
McGuirk, Joseph
Munker, Reinhold
[J]. BLOOD ADVANCES, 2022, 6 (01) : 339 - 357

← 1 2 →