First complete remission favours haploidentical haematopoietic stem cell transplantation with post-transplant cyclophosphamide over cord blood transplantation in acute lymphoblastic leukaemia

被引：1

作者：

Jo, Tomoyasu ^{[1
,2
]}

Ueda, Tomoaki ^{[3
]}

Akahoshi, Yu ^{[4
]}

Kondo, Tadakazu ^{[1
,5
]}

Uchida, Naoyuki ^{[6
]}

Tanaka, Masatsugu ^{[7
]}

Nakamae, Hirohisa ^{[8
]}

Doki, Noriko ^{[9
]}

Ota, Shuichi ^{[10
]}

Sawa, Masashi ^{[11
]}

Ohigashi, Hiroyuki ^{[12
]}

Maruyama, Yumiko ^{[13
]}

Takayama, Nobuyuki ^{[14
]}

Nishida, Tetsuya ^{[15
]}

Hiramoto, Nobuhiro ^{[5
]}

Katayama, Yuta ^{[16
,17
]}

Kanda, Yoshinobu ^{[18
]}

Ichinohe, Tatsuo ^{[19
]}

Atsuta, Yoshiko ^{[20
,21
]}

Arai, Yasuyuki ^{[1
,2
]}

机构：

[1] Kyoto Univ, Grad Sch Med, Dept Hematol & Oncol, Kyoto, Japan

[2] Kyoto Univ Hosp, Ctr Res & Applicat Cellular Therapy, 54 Shogoin Kawahara Cho,Sakyo Ku, Kyoto 6068507, Japan

[3] Osaka Univ, Grad Sch Med, Dept Hematol & Oncol, Suita, Japan

[4] Jichi Med Univ, Div Hematol, Saitama Med Ctr, Saitama, Japan

[5] Kobe City Med Ctr Gen Hosp, Dept Hematol, Kobe, Japan

[6] Federat Natl Publ Serv Personnel Mutual Aid Assoc, Dept Hematol, Tokyo, Japan

[7] Kanagawa Canc Ctr, Dept Hematol, Kanagawa, Japan

[8] Osaka Metropolitan Univ Hosp, Dept Hematol, Osaka, Japan

[9] Komagome Hosp, Tokyo Metropolitan Canc & Infect Dis Ctr, Hematol Div, Tokyo, Japan

[10] Sapporo Hokuyu Hosp, Dept Hematol, Sapporo, Japan

[11] Anjo Kosei Hosp, Dept Hematol & Oncol, Anjo, Japan

[12] Hokkaido Univ Hosp, Dept Hematol, Sapporo, Hokkaido, Japan

[13] Univ Tsukuba Hosp, Dept Hematol, Tsukuba, Japan

[14] Kyorin Univ Hosp, Dept Hematol, Mitaka, Japan

[15] Nagoya Daiichi Hosp, Japanese Red Cross Aichi Med Ctr, Dept Hematol, Nagoya, Japan

[16] Hiroshima Red Cross Hosp, Dept Hematol, Hiroshima, Japan

[17] Atom Bomb Survivors Hosp, Hiroshima, Japan

[18] Jichi Med Univ, Div Hematol, Shimotsuke, Tochigi, Japan

[19] Hiroshima Univ, Res Inst Radiat Biol & Med, Dept Hematol & Oncol, Hiroshima, Japan

[20] Japanese Data Ctr Hematopoiet Cell Transplantat, Nagoya, Japan

[21] Aichi Med Univ, Sch Med, Dept Registry Sci Transplant & Cellular Therapy, Nagakute, Japan

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 2024年 / 204卷 / 05期

关键词：

acute lymphoblastic leukaemia; HLA-haploidentical stem cell transplantation using post-transplant cyclophosphamide; umbilical cord blood; BONE-MARROW-TRANSPLANTATION; TRUMP DATA; SCRIPTS;

D O I：

10.1111/bjh.19372

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

To assess the benefits of HLA-haploidentical haematopoietic stem cell transplantation using post-transplant cyclophosphamide (PTCy-haplo) relative to those of umbilical cord blood (UCB) transplantation in acute lymphoblastic leukaemia (ALL), we analysed 1999 patients (PTCy-haplo, 330; UCB, 1669), using the nationwide Japanese registry. PTCy-haplo was associated with a significantly higher relapse rate, but lower non-relapse mortality, which results in overall survival and disease-free survival, comparable to those of UCB. Among patients in CR1, PTCy-haplo showed a significantly higher survival than UCB regardless of the CD34+ cell dose. Our findings provide valuable insights into the donor selection algorithm in allogeneic HSCT for adult patients with ALL.

引用

页码：1913 / 1919

页数：7

共 15 条

[1] Introduction of Transplant Registry Unified Management Program 2 (TRUMP2): scripts for TRUMP data analyses, part I (variables other than HLA-related data)
Atsuta, Yoshiko
[J]. INTERNATIONAL JOURNAL OF HEMATOLOGY, 2016, 103 (01) : 3 - 10
[2] Alternative donor transplantation after reduced intensity conditioning: results of parallel phase 2 trials using partially HLA-mismatched related bone marrow or unrelated double umbilical cord blood grafts
Brunstein, Claudio G.
Fuchs, Ephraim J.
Carter, Shelly L.
Karanes, Chatchada
Costa, Luciano J.
Wu, Juan
Devine, Steven M.
Wingard, John R.
Aljitawi, Omar S.
Cutler, Corey S.
Jagasia, Madan H.
Ballen, Karen K.
Eapen, Mary
O'Donnell, Paul V.
[J]. BLOOD, 2011, 118 (02) : 282 - 288
[3] Shortened-Duration Immunosuppressive Therapy after Nonmyeloablative, Related HLA-Haploidentical or Unrelated Peripheral Blood Grafts and Post-Transplantation Cyclophosphamide
DeZern, Amy E.
Elmariah, Hany
Zahurak, Marianna
Rosner, Gary L.
Gladstone, Douglas E.
Ali, Syed Abbas
Huff, Carol Ann
Swinnen, Lode J.
Imus, Phil
Borrello, Ivan
Wagner-Johnston, Nina D.
Ambinder, Richard F.
Brodsky, Robert A.
Cooke, Kenneth
Luznik, Leo
Fuchs, Ephraim J.
Bolanos-Meade, Javier
Jones, Richard J.
[J]. BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 2020, 26 (11) : 2075 - 2081
[4] Double unrelated umbilical cord blood vs HLA-haploidentical bone marrow transplantation: the BMT CTN 1101 trial
Fuchs, Ephraim J.
O'Donnell, Paul V.
Eapen, Mary
Logan, Brent
Antin, Joseph H.
Dawson, Peter
Devine, Steven
Horowitz, Mary M.
Horwitz, Mitchell E.
Karanes, Chatchada
Leifer, Eric
Magenau, John M.
McGuirk, Joseph P.
Morris, Lawrence E.
Rezvani, Andrew R.
Jones, Richard J.
Brunstein, Claudio G.
[J]. BLOOD, 2021, 137 (03) : 420 - 428
[5] Impact of infused CD34+stem cell dosing for allogeneic peripheral blood stem cell transplantation with post-transplant cyclophosphamide
Hany, Elmariah
Naqvi, Syeda Mahrukh Hussnain
Kim, Jongphil
Nishihori, Taiga
Mishra, Asmita
Perez, Lia
Faramand, Rawan
Lazaryan, Aleksandr
Liu, Hien D.
Khimani, Farhad
Nieder, Michael
Anasetti, Claudio
Pidala, Joseph
Bejanyan, Nelli
[J]. BONE MARROW TRANSPLANTATION, 2021, 56 (07) : 1683 - 1690
[6] Allogeneic Hematopoietic Stem Cell Transplantation for Adult Philadelphia Chromosome-Negative B-Cell Acute Lymphoblastic Leukemia in Second Complete Remission
Kaito, Satoshi
Kurosawa, Shuhei
Najima, Yuho
Sakaida, Emiko
Shingai, Naoki
Fukuda, Takahiro
Tachibana, Takayoshi
Uchida, Naoyuki
Ozawa, Yukiyasu
Sawa, Masashi
Nakazawa, Hideyuki
Ota, Shuichi
Kato, Jun
Nakamae, Hirohisa
Katayama, Yuta
Eto, Tetsuya
Tanaka, Junji
Kanda, Yoshinobu
Atsuta, Yoshiko
Arai, Yasuyuki
Kako, Shinichi
[J]. TRANSPLANTATION AND CELLULAR THERAPY, 2022, 28 (06): : 326.e1 - 326.e10
[7] Scripts for TRUMP data analyses. Part II (HLA-related data): statistical analyses specific for hematopoietic stem cell transplantation
Kanda, Junya
[J]. INTERNATIONAL JOURNAL OF HEMATOLOGY, 2016, 103 (01) : 11 - 19
[8] Effect of graft-versus-host disease on the outcome of bone marrow transplantation from an HLA-identical sibling donor using GVHD prophylaxis with cyclosporin A and methotrexate
Kanda, Y
Izutsu, K
Hirai, H
Sakamaki, H
Iseki, T
Kodera, Y
Okamoto, S
Mitsui, H
Iwato, K
Hirabayashi, N
Furukawa, T
Maruta, A
Kasai, M
Atsuta, Y
Hamajima, N
Hiraoka, A
Kawa, K
[J]. LEUKEMIA, 2004, 18 (05) : 1013 - 1019
[9] Posttransplant cyclophosphamide contributes to the impairment of the graft-versus-leukemia effect and the amelioration of graft-versus-host disease with the suppression of alloreactive T cells in a murine stem cell transplant model
Makuuchi, Yosuke
Nakashima, Yasuhiro
Nishimoto, Mitsutaka
Koh, Hideo
Hino, Masayuki
Nakamae, Hirohisa
[J]. EXPERIMENTAL HEMATOLOGY, 2023, 123 : 56 - 65
[10] Cord-Blood Transplantation in Patients with Minimal Residual Disease
Milano, Filippo
Gooley, Ted
Wood, Brent
Woolfrey, Ann
Flowers, Mary E.
Doney, Kristine
Witherspoon, Robert
Mielcarek, Marco
Deeg, Joachim H.
Sorror, Mohamed
Dahlberg, Ann
Sandmaier, Brenda M.
Salit, Rachel
Petersdorf, Effie
Appelbaum, Frederick R.
Delaney, Colleen
[J]. NEW ENGLAND JOURNAL OF MEDICINE, 2016, 375 (10) : 944 - 953

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