Lipid-based formulations: A promising approach for poorly soluble drug delivery via the intestinal lymphatic system

被引：9
作者：
Yan, Shujing [1 ]
Cheng, Yuexuan [1 ]
Li, Liangyun [1 ]
Zhong, Chunhong [1 ]
Chen, Chunli [1 ,2 ,3 ]
Gao, Xiaoli [1 ,2 ,3 ]
机构：
[1] Xinjiang Med Univ, Coll Pharm, Urumqi 830011, Xinjiang, Peoples R China
[2] Minist Educ, Engn Res Ctr Xinjiang & Cent Asian Med Resources, Urumqi 830011, Xinjiang, Peoples R China
[3] Xinjiang Key Lab Act Components & Drug Release Tec, Urumqi 830011, Xinjiang, Peoples R China
来源：
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY | 2023年 / 87卷
关键词：
Intestinal lymphatic system; Oral delivery; Lipid -based formulation; Experimental model; FLOW BLOCKING APPROACH; IMPROVED ORAL BIOAVAILABILITY; IN-VIVO CORRELATION; LINEAR CORRELATION; VITRO LIPOLYSIS; TRANSPORT; ABSORPTION; NANOEMULSION; PRODRUG; MODEL;
D O I：
10.1016/j.jddst.2023.104770
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Lipid-based formulation (LBF) has attracted more and more attention as it can significantly improve the effi-ciency of oral delivery of poorly soluble drugs by exploiting the specific absorption pathway of lipids in the intestinal lymphatic system. Based on the structure and function of the intestinal lymphatic system, this article describes the advantages and strategies of oral LBF delivery through this system, highlights the research progress of oral LBF (lipid-based nanocarriers, lipid-based prodrugs) based on this system in recent years, and briefly outlines the experimental model to study the intestinal lymphatic delivery of drugs, providing methods and ideas for the development and utilization of poorly soluble drugs and the rational design of LBF.
引用
收藏
页数：12
相关论文
共 161 条
[31]   Investigating the Impact of Crohn's Disease on the Bioaccessibility of a Lipid-Based Formulation with an In Vitro Dynamic Gastrointestinal Model [J].
Effinger, Angela ;
McAllister, Mark ;
Tomaszewska, Irena ;
O'Driscoll, Caitriona M. ;
Taylor, Mark ;
Gomersall, Steve ;
Heaton, James ;
Smith, Kieran L. ;
Sarcevica, Inese ;
Young, Sam L. ;
Fotaki, Nikoletta .
MOLECULAR PHARMACEUTICS, 2021, 18 (04) :1530-1543
[32]   Lymphatic Connexins and Pannexins in Health and Disease [J].
Ehrlich, Avigail ;
Molica, Filippo ;
Hautefort, Aurelie ;
Kwak, Brenda R. .
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2021, 22 (11)
[33]   Nanostructured lipid carriers (NLCs) as drug delivery platform: Advances in formulation and delivery strategies [J].
Elmowafy, Mohammed ;
Al-Sanea, Mohammad M. .
SAUDI PHARMACEUTICAL JOURNAL, 2021, 29 (09) :999-1012
[34]   Bioactive-Chylomicrons for Oral Lymphatic Targeting of Berberine Chloride: Novel Flow-Blockage Assay in Tissue-Based and Caco-2 Cell Line Models [J].
Elsheikh, Manal A. ;
Elnaggar, Yosra S. R. ;
Otify, Dina Y. ;
Abdallah, Ossama Y. .
PHARMACEUTICAL RESEARCH, 2018, 35 (01)
[35]   Simultaneous assessment of in vitro lipolysis and permeation in the mucus-PVPA model to predict oral absorption of a poorly water soluble drug in SNEDDSs [J].
Falavigna, Margherita ;
Brurok, Sunniva ;
Klitgaard, Mette ;
Flaten, Goril Eide .
INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2021, 596
[36]   Pluronic L81 enhances triacylglycerol accumulation in the cytosol and inhibits chylomicron secretion [J].
Fatma, Sumbul ;
Yakubov, Reuven ;
Anwar, Kamran ;
Hussain, M. Mahmood .
JOURNAL OF LIPID RESEARCH, 2006, 47 (11) :2422-2432
[37]   Emerging insights on drug delivery by fatty acid mediated synthesis of lipophilic prodrugs as novel nanomedicines [J].
Fattahi, Nadia ;
Shahbazi, Mohammad-Ali ;
Maleki, Aziz ;
Hamidi, Mehrdad ;
Ramazani, Ali ;
Santos, Helder A. .
JOURNAL OF CONTROLLED RELEASE, 2020, 326 :556-598
[38]   Vegetable oils composition affects the intestinal lymphatic transport and systemic bioavailability of co-administered lipophilic drug cannabidiol [J].
Feng, Wanshan ;
Qin, Chaolong ;
Abdelrazig, Salah ;
Bai, Ziyu ;
Raji, Mekha ;
Darwish, Randa ;
Chu, YenJu ;
Ji, Liuhang ;
Gray, David A. ;
Stocks, Michael J. ;
Constantinescu, Cris S. ;
Barrett, David A. ;
Fischer, Peter M. ;
Gershkovich, Pavel .
INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2022, 624
[39]   Potential of Lipoprotein-Based Nanoparticulate Formulations for the Treatment of Eye Diseases [J].
Fukuda, Ryosuke ;
Murakami, Tatsuya .
BIOLOGICAL & PHARMACEUTICAL BULLETIN, 2020, 43 (04) :596-607
[40]   Self-assembly drug conjugates for anticancer treatment [J].
Fumagalli, Gaia ;
Marucci, Cristina ;
Christodoulou, Michael S. ;
Stella, Barbara ;
Dosio, Franco ;
Passarella, Daniele .
DRUG DISCOVERY TODAY, 2016, 21 (08) :1321-1329
12345678910