Lipid-based formulations: A promising approach for poorly soluble drug delivery via the intestinal lymphatic system

被引：9
作者：
Yan, Shujing [1 ]
Cheng, Yuexuan [1 ]
Li, Liangyun [1 ]
Zhong, Chunhong [1 ]
Chen, Chunli [1 ,2 ,3 ]
Gao, Xiaoli [1 ,2 ,3 ]
机构：
[1] Xinjiang Med Univ, Coll Pharm, Urumqi 830011, Xinjiang, Peoples R China
[2] Minist Educ, Engn Res Ctr Xinjiang & Cent Asian Med Resources, Urumqi 830011, Xinjiang, Peoples R China
[3] Xinjiang Key Lab Act Components & Drug Release Tec, Urumqi 830011, Xinjiang, Peoples R China
来源：
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY | 2023年 / 87卷
关键词：
Intestinal lymphatic system; Oral delivery; Lipid -based formulation; Experimental model; FLOW BLOCKING APPROACH; IMPROVED ORAL BIOAVAILABILITY; IN-VIVO CORRELATION; LINEAR CORRELATION; VITRO LIPOLYSIS; TRANSPORT; ABSORPTION; NANOEMULSION; PRODRUG; MODEL;
D O I：
10.1016/j.jddst.2023.104770
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Lipid-based formulation (LBF) has attracted more and more attention as it can significantly improve the effi-ciency of oral delivery of poorly soluble drugs by exploiting the specific absorption pathway of lipids in the intestinal lymphatic system. Based on the structure and function of the intestinal lymphatic system, this article describes the advantages and strategies of oral LBF delivery through this system, highlights the research progress of oral LBF (lipid-based nanocarriers, lipid-based prodrugs) based on this system in recent years, and briefly outlines the experimental model to study the intestinal lymphatic delivery of drugs, providing methods and ideas for the development and utilization of poorly soluble drugs and the rational design of LBF.
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页数：12
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