Kaempferol: A flavonoid with wider biological activities and its applications

被引：146
作者：
Bangar, Sneh Punia [1 ]
Chaudhary, Vandana [2 ]
Sharma, Nitya [3 ]
Bansal, Vasudha [4 ]
Ozogul, Fatih [5 ]
Lorenzo, Jose M. [6 ,7 ]
机构：
[1] Clemson Univ, Dept Food Nutr & Packaging Sci, Clemson, SC 29634 USA
[2] Lala Lajpat Rai Univ Vet & Anim Sci, Coll Dairy Sci & Technol, Hisar, Haryana, India
[3] Indian Inst Technol, Ctr Rural Dev & Technol, Food Customizat Res Lab, Delhi, India
[4] Govt Home Sci Coll, Dept Foods & Nutr, Chandigarh, India
[5] Cukurova Univ, Fac Fisheries, Dept Seafood Proc Technol, Adana, Turkey
[6] Ctr Tecnol Carne Galicia, Orense, Spain
[7] Univ Vigo, Fac Ciencias Ourense, Area Tecnol Alimentos, Orense, Spain
来源：
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION | 2023年 / 63卷 / 28期
关键词：
Flavonoids; flavonols; biosynthesis; bioactivities; bioavailability; IN-VITRO; ANTIOXIDANT ACTIVITIES; CYTOTOXIC PROPERTIES; ESCHERICHIA-COLI; DELIVERY-SYSTEMS; CANCER CELLS; LUNG-CANCER; GLYCOSIDES; EXTRACTION; QUERCETIN;
D O I：
10.1080/10408398.2022.2067121
中图分类号：
TS2 [食品工业];
学科分类号：
0832 ;
摘要：
Kaempferol and its derivatives are naturally occurring phytochemicals with promising bioactivities. This flavonol can reduce the lipid oxidation in the human body, prevent the organs and cell structure from deterioration and protect their functional integrity. This review has extensively highlighted the antioxidant, antimicrobial, anticancer, neuroprotective, and hepatoprotective activity of kaempferol. However, poor water solubility and low bioavailability of kaempferol greatly limit its applications. The utilization of advanced delivery systems can improve its stability, efficacy, and bioavailability. This is the first review that aimed to comprehensively collate some of the vital information published on biosynthesis, mechanism of action, bioactivities, bioavailability, and toxicological potential of kaempferol. Besides, it provides insights into the future direction on the improvement of bioavailability of kaempferol for wide applications.
引用
收藏
页码：9580 / 9604
页数：25
相关论文
共 174 条
[41]   Biosynthesis and engineering of kaempferol in Saccharomyces cerevisiae [J].
Duan, Lijin ;
Ding, Wentao ;
Liu, Xiaonan ;
Cheng, Xiaozhi ;
Cai, Jing ;
Hua, Erbing ;
Jiang, Huifeng .
MICROBIAL CELL FACTORIES, 2017, 16
[42]   Absorption of kaempferol from endive, a source of kaempferol-3-glucuronide, in humans [J].
DuPont, MS ;
Day, AJ ;
Bennett, RN ;
Mellon, FA ;
Kroon, PA .
EUROPEAN JOURNAL OF CLINICAL NUTRITION, 2004, 58 (06) :947-954
[43]   Phytochemical investigation, antimicrobial and cytotoxic activities of suspension cultures of Lepidium sativum L. [J].
El-Haggar, Miran ;
El-Hosseiny, Lobna ;
Ghazy, Nabila M. ;
El-Fiky, Fathy Kandeel ;
El-Hawiet, Amr .
SOUTH AFRICAN JOURNAL OF BOTANY, 2021, 138 :500-505
[44]   Kaempferol protects against cadmium chloride -induced hippocampal damage and memory de ficits by activation of silent information regulator 1 and inhibition of poly (ADP -Ribose) polymerase-1 [J].
El-kott, Attalla Farag ;
Abd-Lateif, Abd-El-Karim M. ;
Khalifa, Heba S. ;
Morsy, Kareem ;
Ibrahim, Essam H. ;
Bin-Jumah, May ;
Abdel-Daim, Mohamed M. ;
Aleya, Lotfi .
SCIENCE OF THE TOTAL ENVIRONMENT, 2020, 728
[45]   Kaempferol inhibits Nrf2 signalling pathway via downregulation of Nrf2 mRNA and induces apoptosis in NSCLC cells [J].
Fouzder, Chandrani ;
Mukhuty, Alpana ;
Kundu, Rakesh .
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 2021, 697
[46]   Antifungal effects of the flavonoids kaempferol and quercetin: a possible alternative for the control of fungal biofilms [J].
Gadelha Rocha, Marcos Fabio ;
Sales, Jamille Alencar ;
da Rocha, Maria Gleiciane ;
Galdino, Livia Maria ;
de Aguiar, Lara ;
Pereira-Neto, Waldemiro de Aquino ;
Cordeiro, Rossana de Aguiar ;
Collares Maia Castelo-Branco, Debora de Souza ;
Costa Sidrim, Jose Julio ;
Nogueira Brilhante, Raimunda Samia .
BIOFOULING, 2019, 35 (03) :320-328
[47]   Antidepressive effects of kaempferol mediated by reduction of oxidative stress, proinflammatory cytokines and up-regulation of AKT/β-catenin cascade [J].
Gao, Wenqi ;
Wang, Wei ;
Peng, Yan ;
Deng, Zhifang .
METABOLIC BRAIN DISEASE, 2019, 34 (02) :485-494
[48]   Kaempferol Induces G2/M Cell Cycle Arrest via Checkpoint Kinase 2 and Promotes Apoptosis via Death Receptors in Human Ovarian Carcinoma A2780/CP70 Cells [J].
Gao, Ying ;
Yin, Junfeng ;
Rankin, Gary O. ;
Chen, Yi Charlie .
MOLECULES, 2018, 23 (05)
[49]   Kaempferol conjugated gold nanoclusters enabled efficient for anticancer therapeutics to A549 lung cancer cells [J].
Govindaraju, Saravanan ;
Roshini, Arivazhagan ;
Lee, Min-Ho ;
Yun, Kyusik .
INTERNATIONAL JOURNAL OF NANOMEDICINE, 2019, 14 :5147-5157
[50]   Anti-inflammatory effects of kaempferol, myricetin, fisetin and ibuprofen in neonatal rats [J].
Guo, Peng ;
Feng, Yun-Yun .
TROPICAL JOURNAL OF PHARMACEUTICAL RESEARCH, 2017, 16 (08) :1819-1826
12345678910