Kaempferol: A flavonoid with wider biological activities and its applications

被引：145

作者：

Bangar, Sneh Punia ^{[1
]}

Chaudhary, Vandana ^{[2
]}

Sharma, Nitya ^{[3
]}

Bansal, Vasudha ^{[4
]}

Ozogul, Fatih ^{[5
]}

Lorenzo, Jose M. ^{[6
,7
]}

机构：

[1] Clemson Univ, Dept Food Nutr & Packaging Sci, Clemson, SC 29634 USA

[2] Lala Lajpat Rai Univ Vet & Anim Sci, Coll Dairy Sci & Technol, Hisar, Haryana, India

[3] Indian Inst Technol, Ctr Rural Dev & Technol, Food Customizat Res Lab, Delhi, India

[4] Govt Home Sci Coll, Dept Foods & Nutr, Chandigarh, India

[5] Cukurova Univ, Fac Fisheries, Dept Seafood Proc Technol, Adana, Turkey

[6] Ctr Tecnol Carne Galicia, Orense, Spain

[7] Univ Vigo, Fac Ciencias Ourense, Area Tecnol Alimentos, Orense, Spain

来源：

CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION | 2023年 / 63卷 / 28期

关键词：

Flavonoids; flavonols; biosynthesis; bioactivities; bioavailability; IN-VITRO; ANTIOXIDANT ACTIVITIES; CYTOTOXIC PROPERTIES; ESCHERICHIA-COLI; DELIVERY-SYSTEMS; CANCER CELLS; LUNG-CANCER; GLYCOSIDES; EXTRACTION; QUERCETIN;

D O I：

10.1080/10408398.2022.2067121

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

Kaempferol and its derivatives are naturally occurring phytochemicals with promising bioactivities. This flavonol can reduce the lipid oxidation in the human body, prevent the organs and cell structure from deterioration and protect their functional integrity. This review has extensively highlighted the antioxidant, antimicrobial, anticancer, neuroprotective, and hepatoprotective activity of kaempferol. However, poor water solubility and low bioavailability of kaempferol greatly limit its applications. The utilization of advanced delivery systems can improve its stability, efficacy, and bioavailability. This is the first review that aimed to comprehensively collate some of the vital information published on biosynthesis, mechanism of action, bioactivities, bioavailability, and toxicological potential of kaempferol. Besides, it provides insights into the future direction on the improvement of bioavailability of kaempferol for wide applications.

引用

页码：9580 / 9604

页数：25

共 174 条

[1] Extraction and Isolation of Kaempferol Glycosides from the Leaves and Twigs of Lindera neesiana [J].

Adhikari-Devkota, Anjana ;

Dirar, Amina Ibrahim ;

Kurizaki, Ayumi ;

Tsushiro, Kazuki ;

Devkota, Hari Prasad .

SEPARATIONS, 2019, 6 (01)

[2] Possible Role of Kaempferol in Reversing Oxidative Damage, Inflammation, and Apoptosis-Mediated Cortical Injury Following Cadmium Exposure [J].

Al-Brakati, Ashraf ;

Albarakati, Alaa Jameel A. ;

Lokman, Maha S. ;

Theyab, Abdulrahman ;

Algahtani, Mohammad ;

Menshawi, Salah ;

AlAmri, Ohoud D. ;

Al Omairi, Naif E. ;

Essawy, Ehab A. ;

Kassab, Rami B. ;

Moneim, Ahmed E. Abdel .

NEUROTOXICITY RESEARCH, 2021, 39 (02) :198-209

[3] Ellagic Acid, Kaempferol, and Quercetin from Acacia nilotica: Promising Combined Drug With Multiple Mechanisms of Action [J].

Al-Nour M.Y. ;

Ibrahim M.M. ;

Elsaman T. .

Current Pharmacology Reports, 2019, 5 (4) :255-280

[4] Kaempferol as a Dietary Anti-Inflammatory Agent: Current Therapeutic Standing [J].

Alam, Waqas ;

Khan, Haroon ;

Shah, Muhammad Ajmal ;

Cauli, Omar ;

Saso, Luciano .

MOLECULES, 2020, 25 (18)

[5] Inhibition of miR31 and miR92a as Oncological Biomarkers in RKO Colon Cancer Cells Treated with Kaempferol-3-O-Glycoside Isolated from Black Bean [J].

Alejandra Gutierrez-Uribe, Janet ;

Salinas-Santander, Mauricio ;

Serna-Guerrero, Delia ;

Othon Serna-Saldivar, Sergio Roman ;

Maria Rivas-Estilla, Ana ;

Patricia Rios-Ibarra, Clara .

JOURNAL OF MEDICINAL FOOD, 2020, 23 (01) :50-55

[6] Optimization of Ultrasonicated Kaempferol Extraction from Ocimum basilicum Using a Box-Behnken Design and Its Densitometric Validation [J].

Altemimi, Ammar B. ;

Mohammed, Muthanna J. ;

Yi-Chen, Lee ;

Watson, Dennis G. ;

Lakhssassi, Naoufal ;

Cacciola, Francesco ;

Ibrahim, Salam A. .

FOODS, 2020, 9 (10)

[7] Modulation of the Activity of ABC Transporters (P-Glycoprotein, MRP2, BCRP) by Flavonoids and Drug Response [J].

Alvarez, Ana I. ;

Real, Rebeca ;

Perez, Miriam ;

Mendoza, Gracia ;

Prieto, Julio G. ;

Merino, Gracia .

JOURNAL OF PHARMACEUTICAL SCIENCES, 2010, 99 (02) :598-617

[8] Therapeutic effects of kaempferol affecting autophagy and endoplasmic reticulum stress [J].

Ashrafizadeh, Milad ;

Tavakol, Shima ;

Ahmadi, Zahra ;

Roomiani, Sahar ;

Mohammadinejad, Reza ;

Samarghandian, Saeed .

PHYTOTHERAPY RESEARCH, 2020, 34 (05) :911-923

[9] The Best Extraction Technique for Kaempferol and Quercetin Isolation from Guava Leaves (Psidium guajava']java) [J].

Batubara, I. ;

Suparto, I. H. ;

Wulandari, N. S. .

3RD INTERNATIONAL SEMINAR ON SCIENCES SCIENCES ON PRECISION AND SUSTAINABLE AGRICULTURE (ISS-2016), 2017, 58

[10] Kaempferol, a new nutrition-derived pan-inhibitor of human histone deacetylases [J].

Berger, Alexander ;

Venturelli, Sascha ;

Kallnischkies, Mascha ;

Boecker, Alexander ;

Busch, Christian ;

Weiland, Timo ;

Noor, Seema ;

Leischner, Christian ;

Weiss, Thomas S. ;

Lauer, Ulrich M. ;

Bischoff, Stephan C. ;

Bitzer, Michael .

JOURNAL OF NUTRITIONAL BIOCHEMISTRY, 2013, 24 (06) :977-985

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