Inhibition of CD40L with frexalimab blunts innate immune responses to activated T cells

被引：0
|
作者：
Proto, Jonathan [1 ]
Blazier, Anna [1 ]
Cheong, Agnes [1 ]
Teeple, Erin [1 ]
Nouri, Nima [1 ]
Savova, Virginia [1 ]
Djukic, Biljana [1 ]
Ofengeim, Dimitry [1 ]
机构：
[1] Sanofi, Cambridge, MA USA
来源：
MULTIPLE SCLEROSIS JOURNAL | 2023年 / 29卷
关键词：
D O I：
暂无
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
P1279/2187
引用
收藏
页码：812 / 812
页数：1
相关论文
共 50 条
  • [11] CD40L expression is sustained on activated T cells by CD28-dependent IL-2 production: role of CD40L in B cell help.
    Lee, B
    Haynes, L
    Swain, S
    Lund, F
    Randall, T
    FASEB JOURNAL, 2001, 15 (04): : A344 - A344
  • [12] CD40L expression by CD4+ but not CD8+ T cells regulates antiviral immune responses in acute LCMV infection in mice
    Durlanik, Sibel
    Loyal, Lucie
    Stark, Regina
    Alp, Ozen Sercan
    Hartung, Anett
    Radbruch, Andreas
    von Herrath, Matthias
    Matzmohr, Nadine
    Frentsch, Marco
    Thiel, Andreas
    EUROPEAN JOURNAL OF IMMUNOLOGY, 2016, 46 (11) : 2566 - 2573
  • [13] MYC inhibition reprograms tumor immune microenvironment by recruiting T lymphocytes and activating the CD40/CD40L system in osteosarcoma
    Jiang, Kuo
    Zhang, Qianfeng
    Fan, Yong
    Li, Jia
    Zhang, Jitao
    Wang, Wentao
    Fan, Jinzhu
    Guo, Yunshan
    Liu, Shichang
    Hao, Dingjun
    Wang, Yongxiang
    Wang, Lei
    Shan, Lequn
    CELL DEATH DISCOVERY, 2022, 8 (01)
  • [14] MYC inhibition reprograms tumor immune microenvironment by recruiting T lymphocytes and activating the CD40/CD40L system in osteosarcoma
    Kuo Jiang
    Qianfeng Zhang
    Yong Fan
    Jia Li
    Jitao Zhang
    Wentao Wang
    Jinzhu Fan
    Yunshan Guo
    Shichang Liu
    Dingjun Hao
    Yongxiang Wang
    Lei Wang
    Lequn Shan
    Cell Death Discovery, 8
  • [15] CD40L IS EXPRESSED ON ACTIVATED CELLS OF SEZARY PATIENTS WITH ELEVATED IGE
    BIGLER, RD
    BOSELLI, C
    SPRIGGS, MK
    ARMITAGE, RJ
    VONDERHEID, EC
    FASEB JOURNAL, 1994, 8 (05): : A1006 - A1006
  • [16] MECHANISTIC ROLE OF CD40/CD40L ON T-CELLS IN THE FIELD OF TRANSPLANTATION
    Granofszky, N.
    Hock, K.
    Mahr, B.
    Pilat-Michalek, N.
    Wekerle, T.
    TRANSPLANT INTERNATIONAL, 2016, 29 : 19 - 19
  • [17] Modulating Immune Responses: The Double-Edged Sword of Platelet CD40L
    Bendas, Gerd
    Gobec, Martina
    Schlesinger, Martin
    SEMINARS IN THROMBOSIS AND HEMOSTASIS, 2024,
  • [18] Copy number of the X-linked genes TLR7 and CD40L influences innate and adaptive immune responses
    Sarmiento, Luis
    Svensson, Johan
    Barchetta, Ilaria
    Giwercman, Aleksander
    Cilio, Corrado M.
    SCANDINAVIAN JOURNAL OF IMMUNOLOGY, 2019, 90 (02)
  • [19] CD40L induces non-T cell dependent anti-leukemic immune responses.
    Gruber, TA
    Skelton, DC
    Kohn, DB
    BLOOD, 2000, 96 (11) : 118A - 119A
  • [20] Role of CD8+ T cells in innate immune responses
    Berg, RE
    Forman, J
    FASEB JOURNAL, 2002, 16 (04): : A287 - A287
12345