The current landscape of m6A modification in urological cancers

被引：1
|
作者：
Zeng, Yaohui [1 ]
Lv, Cai [1 ]
Wan, Bangbei [1 ]
Gong, Binghao [1 ]
机构：
[1] Cent South Univ, Dept Urol, Xiangya Sch Med, Affiliated Haikou Hosp, Haikou, Peoples R China
来源：
PEERJ | 2023年 / 11卷
关键词：
N6-methyladenosine; Renal cell carcinoma; Bladder cancer; Prostate cancer; Epigenetic modifications; Urological cancer; RNA METHYLATION REGULATORS; METHYLTRANSFERASE METTL3 PROMOTES; MESSENGER-RNA; GENE-EXPRESSION; BLADDER-CANCER; PROGRESSION; FTO; TRANSLATION; METASTASIS; CARCINOMA;
D O I：
10.7717/peerj.16023
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
N6-methyladenosine (m6A) methylation is a dynamic and reversible procession of epigenetic modifications. It is increasingly recognized that m6A modification has been involved in the tumorigenesis, development, and progression of urological tumors. Emerging research explored the role of m6A modification in urological cancer. In this review, we will summarize the relationship between m6A modification, renal cell carcinoma, bladder cancer, and prostate cancer, and discover the biological function of m6A regulators in tumor cells. We will also discuss the possible mechanism and future application value used as a potential biomarker or therapeutic target to benefit patients with urological cancers.
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页数：24
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