Research Progress of m6A RNA Methylation in Skin Diseases

被引：4

作者：

Liu, Chang ^{[1
]}

Wang, Xin ^{[1
]}

Yang, Shengju ^{[1
]}

Cao, Shuanglin ^{[1
]}

机构：

[1] Nantong Univ, Med Sch, Affiliated Hosp, Dept Dermatol, Nantong 226001, Peoples R China

来源：

BIOMED RESEARCH INTERNATIONAL | 2023年 / 2023卷

基金：

中国国家自然科学基金;

关键词：

D O I：

10.1155/2023/3091204

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

N-6-Methyladenosine (m(6)A) is the most common mRNA modification in eukaryotes and is a dynamically reversible posttranscriptional modification. The enzymes involved in m(6)A modification mainly include methyltransferases (writers), demethylases (erasers), and methylated readers (Readers). m(6)A modification is mainly catalyzed by m(6)A methyltransferase and removed by m(6)A demethylase. The modified RNA can be specifically recognized and bound by m(6)A recognition protein. This protein complex then mediates RNA splicing, maturation, nucleation, degradation, and translation. m(6)A also alters gene expression and regulates cellular processes such as self-renewal, differentiation, invasion, and apoptosis. An increasing body of evidence indicates that the m(6)A methylation modification process is closely related to the occurrence of various skin diseases. In this review, we discuss the role of m(6)A methylation in skin development and skin diseases including psoriasis, melanoma, and cutaneous squamous cell carcinoma.

引用

页数：10

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