Advancing therapeutic strategies for Epstein-Barr virus-associated malignancies through lytic reactivation

被引：10
作者：
Tan, Haiqi [1 ,2 ]
Gong, Yibing [1 ,2 ]
Liu, Yi [1 ,2 ]
Long, Jingyi [1 ,2 ]
Luo, Qingshuang [1 ,2 ]
Faleti, Oluwasijibomi Damola [1 ,2 ,3 ]
Lyu, Xiaoming [1 ,2 ,4 ,5 ]
机构：
[1] Southern Med Univ, Affiliated Hosp 3, Dept Lab Med, Guangzhou 510630, Peoples R China
[2] Southern Med Univ, Sch Clin Med 3, Guangzhou 510630, Peoples R China
[3] Hong Kong Polytech Univ, Dept Appl Biol & Chem Technol, Hong Kong 999000, Peoples R China
[4] Southern Med Univ, Sch Clin Med 3, Dept Lab Med, Guangzhou 510630, Peoples R China
[5] Southern Med Univ, Affiliated Hosp 3, Guangzhou 510630, Peoples R China
来源：
BIOMEDICINE & PHARMACOTHERAPY | 2023年 / 164卷
基金：
中国国家自然科学基金;
关键词：
EBV; Lytic reactivation; Carcinogenesis; Therapies; HERPES-SIMPLEX-VIRUS; CYTOTOXIC T-LYMPHOCYTES; INFECTED B-CELLS; NASOPHARYNGEAL CARCINOMA; PROTEIN-KINASE; GROWTH-FACTOR; ENHANCES TRANSFORMATION; GENOME INSTABILITY; TRANSACTIVATOR ZTA; OXIDATIVE STRESS;
D O I：
10.1016/j.biopha.2023.114916
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Epstein-Barr virus (EBV) is a widespread human herpes virus associated with lymphomas and epithelial cell cancers. It establishes two separate infection phases, latent and lytic, in the host. Upon infection of a new host cell, the virus activates several pathways, to induce the expression of lytic EBV antigens and the production of infectious virus particles. Although the carcinogenic role of latent EBV infection has been established, recent research suggests that lytic reactivation also plays a significant role in carcinogenesis. In this review, we sum-marize the mechanism of EBV reactivation and recent findings about the role of viral lytic antigens in tumor formation. In addition, we discuss the treatment of EBV-associated tumors with lytic activators and the targets that may be therapeutically effective in the future.
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页数：11
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