Dual-Oxygenation/Dual-Fenton Synergistic Photothermal/Chemodynamic/Starvation Therapy for Tumor Treatment

被引:17
作者
Kang, Hongmei [1 ]
Chen, Lamei [1 ]
Li, Qin [1 ]
Chen, Huan [1 ]
Zhang, Liangke [1 ]
机构
[1] Chongqing Med Univ, Coll Pharm, Chongqing Res Ctr Pharmaceut Engn, Chongqing Key Lab Biochem & Mol Pharmacol, Chongqing, Peoples R China
基金
中国国家自然科学基金;
关键词
photothermal therapy; chemodynamic therapy; starvation therapy; dual-Fenton; synergistic treatment; REDUCED GRAPHENE OXIDE; PHOTODYNAMIC THERAPY; NANOPLATFORM; NANOPARTICLES;
D O I
10.1021/acsami.2c22578
中图分类号
TB3 [工程材料学];
学科分类号
0805 ; 080502 ;
摘要
Due to the complexity of tumor pathogenesis and the heterogeneity of the tumor microenvironment (TME), it is difficult to obtain satisfactory efficacy with a single therapy. In this study, a hyaluronic acid (HA)-modified ruthenium nanoaggregate (RuNA) and glucose oxidase (GOD)-loaded manganese dioxide (MnO2) nanoflowers (MRG@HA) have been prepared. RuNA and MnO2 nanoflowers can generate O2 in TME, alleviating tumor tissue hypoxia. RuNA is a good photothermal agent for high-temperature ablation of solid tumors under infrared laser irradiation. GOD consumes glucose in the presence of O2 and converts it into glucuronic acid and hydrogen peroxide, reducing tumor nutrient supply while promoting Fenton-like reactions of MnO2 nanoflowers and RuNA to produce cytotoxic hydroxyl radicals. MRG@HA can also actively target tumor cells through the affinity of HA and CD44 receptor to improve the antitumor effect. In vitro and in vivo studies have confirmed the synergistic effect of MRG@HA with tumor photothermal/chemodynamic/starvation therapy, showing its great potential for clinical application in tumor therapy.
引用
收藏
页码:15129 / 15139
页数:11
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