Association between Type 1 Diabetes Mellitus and Parkinson's Disease: A Mendelian Randomization Study

被引:5
作者
Mai, Aaron Shengting [1 ,2 ]
Tan, Brendan Jen-Wei [2 ]
Sun, Qiao-Yang [2 ]
Tan, Eng-King [2 ,3 ]
机构
[1] Natl Univ Singapore, Yong Loo Lin Sch Med, Singapore 117597, Singapore
[2] Natl Neurosci Inst, Dept Neurol, Singapore Gen Hosp Campus, Singapore 308433, Singapore
[3] Duke NUS Med Sch, Neurosci & Behav Disorders, Singapore 169857, Singapore
基金
英国医学研究理事会;
关键词
Mendelian randomization; Parkinson's disease; type 1 diabetes mellitus; FinnGen; RISK; INSIGHTS;
D O I
10.3390/jcm13020561
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
While much evidence suggests that type 2 diabetes mellitus increases the risk of Parkinson's disease (PD), the relationship between type 1 diabetes mellitus (T1DM) and PD is unclear. To study their association, we performed a two-sample Mendelian randomization (MR) using the following statistical methods: inverse variance weighting (IVW), MR-Egger, weight median, and weighted mode. Independent datasets with no sample overlap were retrieved from the IEU GWAS platform. All the MR methods found a lower risk of PD in T1DM (IVW-OR 0.93, 95% CI 0.91-0.96, p = 3.12 x 10-5; MR-Egger-OR 0.93, 95% CI 0.88-0.98, p = 1.45 x 10-2; weighted median-OR 0.93, 95% CI 0.89-0.98, p = 2.76 x 10-3; and weighted mode-OR 0.94, 95% CI 0.9-0.98, p = 1.58 x 10-2). The findings were then replicated with another independent GWAS dataset on T1DM (IVW-OR 0.97, 95% CI 0.95-0.99, p = 3.10 x 10-3; MR-Egger-OR 0.96, 95% CI 0.93-0.99, p = 1.08 x 10-2; weighted median-OR 0.97, 95% CI 0.94-0.99, p = 1.88 x 10-2; weighted mode-OR 0.97, 95% CI 0.94-0.99, p = 1.43 x 10-2). Thus, our study provides evidence that T1DM may have a protective effect on PD risk, though further studies are needed to clarify the underlying mechanisms.
引用
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页数:10
相关论文
共 40 条
[1]  
[Anonymous], 2022, NAT REV METHOD PRIME, V2, DOI [10.1038/s43586-022-00099-6, 10.1038/s43586-021-00092-5]
[2]   Long-term and recent trends in survival and life expectancy for people with type 1 diabetes in Finland [J].
Arffman, Martti ;
Hakkarainen, Pirjo ;
Keskimaki, Ilmo ;
Oksanen, Tuula ;
Sund, Reijo .
DIABETES RESEARCH AND CLINICAL PRACTICE, 2023, 198
[3]   The Impact of Type 2 Diabetes in Parkinson's Disease [J].
Athauda, Dilan ;
Evans, James ;
Wernick, Anna ;
Virdi, Gurvir ;
Choi, Minee L. ;
Lawton, Michael ;
Vijiaratnam, Nirosen ;
Girges, Christine ;
Ben-Shlomo, Yoav ;
Ismail, Khalida ;
Morris, Huw ;
Grosset, Donald ;
Foltynie, Thomas ;
Gandhi, Sonia .
MOVEMENT DISORDERS, 2022, 37 (08) :1612-1623
[4]   Diabetes mellitus, prediabetes and the risk of Parkinson's disease: a systematic review and meta-analysis of 15 cohort studies with 29.9 million participants and 86,345 cases [J].
Aune, Dagfinn ;
Schlesinger, Sabrina ;
Mahamat-Saleh, Yahya ;
Zheng, Bang ;
Udeh-Momoh, Chinedu T. T. ;
Middleton, Lefkos T. T. .
EUROPEAN JOURNAL OF EPIDEMIOLOGY, 2023, 38 (06) :591-604
[5]   Diabetes medications and risk of Parkinson's disease: a cohort study of patients with diabetes [J].
Brauer, Ruth ;
Wei, Li ;
Ma, Tiantian ;
Athauda, Dilan ;
Girges, Christine ;
Vijiaratnam, Nirosen ;
Auld, Grace ;
Whittlesea, Cate ;
Wong, Ian ;
Foltynie, Tom .
BRAIN, 2020, 143 :3067-3076
[6]  
Burgess Stephen, 2019, Wellcome Open Res, V4, P186, DOI 10.12688/wellcomeopenres.15555.3
[7]   The effect of type 1 diabetes on the developing brain [J].
Cameron, Fergus J. ;
Northam, Elisabeth A. ;
Ryan, Christopher M. .
LANCET CHILD & ADOLESCENT HEALTH, 2019, 3 (06) :427-436
[8]   Type 2 diabetes [J].
Chatterjee, Sudesna ;
Khunti, Kamlesh ;
Davies, Melanie J. .
LANCET, 2017, 389 (10085) :2239-2251
[9]   The trans-ancestral genomic architecture of glycemic traits [J].
Chen, Ji ;
Spracklen, Cassandra N. ;
Marenne, Gaelle ;
Varshney, Arushi ;
Corbin, Laura J. ;
Luan, Jian'an ;
Willems, Sara M. ;
Wu, Ying ;
Zhang, Xiaoshuai ;
Horikoshi, Momoko ;
Boutin, Thibaud S. ;
Magi, Reedik ;
Waage, Johannes ;
Li-Gao, Ruifang ;
Chan, Kei Hang Katie ;
Yao, Jie ;
Anasanti, Mila D. ;
Chu, Audrey Y. ;
Claringbould, Annique ;
Heikkinen, Jani ;
Hong, Jaeyoung ;
Hottenga, Jouke-Jan ;
Huo, Shaofeng ;
Kaakinen, Marika A. ;
Louie, Tin ;
Maerz, Winfried ;
Moreno-Macias, Hortensia ;
Ndungu, Anne ;
Nelson, Sarah C. ;
Nolte, Ilja M. ;
North, Kari E. ;
Raulerson, Chelsea K. ;
Ray, Debashree ;
Rohde, Rebecca ;
Rybin, Denis ;
Schurmann, Claudia ;
Sim, Xueling ;
Southam, Lorraine ;
Stewart, Isobel D. ;
Wang, Carol A. ;
Wang, Yujie ;
Wu, Peitao ;
Zhang, Weihua ;
Ahluwalia, Tarunveer S. ;
Appel, Emil V. R. ;
Bielak, Lawrence F. ;
Brody, Jennifer A. ;
Burtt, Noel P. ;
Cabrera, Claudia P. ;
Cade, Brian E. .
NATURE GENETICS, 2021, 53 (06) :840-+
[10]   Type 2 Diabetes as a Determinant of Parkinson's Disease Risk and Progression [J].
Chohan, Harneek ;
Senkevich, Konstantin ;
Patel, Radhika K. ;
Bestwick, Jonathan P. ;
Jacobs, Benjamin M. ;
Bandres Ciga, Sara ;
Gan-Or, Ziv ;
Noyce, Alastair J. .
MOVEMENT DISORDERS, 2021, 36 (06) :1420-1429