Glycoprotein 2 as a gut gate keeper for mucosal equilibrium between inflammation and immunity

被引：4

作者：

Zhang, Zhongwei ^{[1
,2
]}

Tanaka, Izumi ^{[1
,2
]}

Nakahashi-Ouchida, Rika ^{[2
,3
,4
,5
]}

Ernst, Peter B. ^{[6
,7
,8
,9
]}

Kiyono, Hiroshi ^{[2
,3
,5
,6
,9
,10
,11
]}

Kurashima, Yosuke ^{[1
,2
,3
,5
,6
,12
,13
]}

机构：

[1] Chiba Univ, Grad Sch Med, Dept Innovat Med, 1-8-1 Inohana,Chuo Ku, Chiba 2608670, Japan

[2] Chiba Univ, Future Mucosal Vaccine Res & Dev Synergy Inst, Chiba, Japan

[3] Chiba Univ, Futurist Mucosal Vaccine Res & Dev Synergy Inst cS, Chiba, Japan

[4] Univ Tokyo, Inst Med Sci, Int Res & Dev Ctr Mucosal Vaccines, Div Mucosal Vaccines, Tokyo, Japan

[5] Chiba Univ Hosp, Dept Human Mucosal Vaccinol, Chiba, Japan

[6] Chiba Univ Univ Calif San Diego Ctr Mucosal Immuno, Sch Med, Dept Med, San Diego, CA 92093 USA

[7] Univ Calif San Diego, Div Comparat Pathol & Med, Dept Pathol, La Jolla, CA USA

[8] Univ Calif San Diego, Ctr Vet Sci & Comparat Med, San Diego, CA USA

[9] Chiba Univ, Future Med Educ & Res Org, Chiba, Japan

[10] HanaVax Inc, Tokyo, Japan

[11] Chiba Univ, Inst Global Prominent Res, Mucosal Immunol & Allergy Therapeut, Chiba, Japan

[12] Univ Tokyo, Inst Med Sci, Int Res & Dev Ctr Mucosal Vaccines, Div Clin Vaccinol, Tokyo, Japan

[13] Chiba Univ, Inst Adv Acad Res, Chiba, Japan

来源：

SEMINARS IN IMMUNOPATHOLOGY | 2024年 / 45卷 / 4-6期

基金：

日本学术振兴会;

关键词：

Mucosal immunology; Pancreas; Glycoprotein; 2; Anti-GP2; autoantibodies; Inflammatory bowel disease; Pancreas-gut axis; GRANULE MEMBRANE-PROTEIN; GPI-ANCHORED PROTEINS; APICAL PLASMA-MEMBRANE; CROHNS-DISEASE; SECRETORY GRANULES; ZYMOGEN GRANULES; BOWEL-DISEASE; RAT PANCREAS; MAJOR GLYCOPROTEIN; ESCHERICHIA-COLI;

D O I：

10.1007/s00281-023-00999-z

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Glycoprotein 2 (GP2) is a widely distributed protein in the digestive tract, contributing to mucosal barrier maintenance, immune homeostasis, and antigen-specific immune response, while also being linked to inflammatory bowel disease (IBD) pathogenesis. This review sheds light on the extensive distribution of GP2 within the gastrointestinal tract and its intricate interplay with the immune system. Furthermore, the significance of GP2 autoantibodies in diagnosing and categorizing IBD is underscored, alongside the promising therapeutic avenues for modulating GP2 to regulate immunity and maintain mucosal balance.

引用

页码：493 / 507

页数：15

共 123 条

[1] Efficient Generation of Glucose-Responsive Beta Cells from Isolated GP2+ Human Pancreatic Progenitors [J].