The Roles of Periodontal Bacteria in Atherosclerosis

被引:20
作者
Huang, Xiaofei [1 ,2 ,3 ]
Xie, Mengru [1 ,2 ,3 ]
Lu, Xiaofeng [1 ,2 ,3 ]
Mei, Feng [1 ,2 ,3 ]
Song, Wencheng [1 ,2 ,3 ]
Liu, Yang [1 ,2 ,3 ]
Chen, Lili [1 ,2 ,3 ]
机构
[1] Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Dept Stomatol, Wuhan 430022, Peoples R China
[2] Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Stomatol, Wuhan 430030, Peoples R China
[3] Hubei Prov Key Lab Oral & Maxillofacial Dev & Rege, Wuhan 430022, Peoples R China
基金
中国国家自然科学基金;
关键词
atherosclerosis; CVD; periodontal pathogens; Porphyromonas gingivalis; Aggregatibacter actinomycetemcomitans; Fusobacterium nucleatum; plaque; instability; PERIPHERAL ARTERIAL-DISEASE; PORPHYROMONAS-GINGIVALIS INFECTION; AGGREGATIBACTER-ACTINOMYCETEMCOMITANS LEUKOTOXIN; PREVOTELLA-INTERMEDIA ATCC-25611; ADHESION MOLECULE-1 EXPRESSION; FIMBRIA-DEPENDENT ACTIVATION; STIMULATES MONOCYTE ADHESION; ALVEOLAR BONE LOSS; ET-AL; 1986; NF-KAPPA-B;
D O I
10.3390/ijms241612861
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Atherosclerosis (AS) is an inflammatory vascular disease that constitutes a major underlying cause of cardiovascular diseases (CVD) and stroke. Infection is a contributing risk factor for AS. Epidemiological evidence has implicated individuals afflicted by periodontitis displaying an increased susceptibility to AS and CVD. This review concisely outlines several prevalent periodontal pathogens identified within atherosclerotic plaques, including Porphyromonas gingivalis, Aggregatibacter actinomycetemcomitans, and Fusobacterium nucleatum. We review the existing epidemiological evidence elucidating the association between these pathogens and AS-related diseases, and the diverse mechanisms for which these pathogens may engage in AS, such as endothelial barrier disruption, immune system activation, facilitation of monocyte adhesion and aggregation, and promotion of foam cell formation, all of which contribute to the progression and destabilization of atherosclerotic plaques. Notably, the intricate interplay among bacteria underscores the complex impact of periodontitis on AS. In conclusion, advancing our understanding of the relationship between periodontal pathogens and AS will undoubtedly offer invaluable insights and potential therapeutic avenues for the prevention and management of AS.
引用
收藏
页数:28
相关论文
共 223 条
[1]   Microbiota, cirrhosis, and the emerging oral-gut-liver axis [J].
Acharya, Chathur ;
Sahingur, Sinem Esra ;
Bajaj, Jasmohan S. .
JCI INSIGHT, 2017, 2 (19)
[2]   Impact of Diabetes Mellitus on Early Clinical Outcome and Stent Restenosis after Carotid Artery Stenting [J].
Achim, Alexandru ;
Lacko, David ;
Huettl, Artur ;
Csobay-Novak, Csaba ;
Csavajda, Adam ;
Sotonyi, Peter ;
Merkely, Bela ;
Nemes, Balazs ;
Ruzsa, Zoltan .
JOURNAL OF DIABETES RESEARCH, 2022, 2022
[3]   Approaches to Peripheral Artery Disease in Diabetes: Are There Any Differences? [J].
Achim, Alexandru ;
Stanek, Agata ;
Homorodean, Calin ;
Spinu, Mihail ;
Onea, Horea Laurentiu ;
Lazar, Leontin ;
Marc, Madalin ;
Ruzsa, Zoltan ;
Olinic, Dan Mircea .
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH, 2022, 19 (16)
[4]  
ADAM E, 1987, LANCET, V2, P291
[5]   Epidemiology of Peripheral Artery Disease and Polyvascular Disease [J].
Aday, Aaron W. ;
Matsushita, Kunihiro .
CIRCULATION RESEARCH, 2021, 128 (12) :1818-1832
[6]   Periodontitis is associated with the risk of subclinical atherosclerosis and peripheral arterial disease in Korean adults [J].
Ahn, Yoo-Been ;
Shin, Myung-Seop ;
Han, Dong-Hun ;
Sukhbaatar, Munkhzaya ;
Kim, Mi-Sun ;
Shin, Hye-Sun ;
Kim, Hyun-Duck .
ATHEROSCLEROSIS, 2016, 251 :311-318
[7]   Salivary IgA to MAA-LDL and Oral Pathogens Are Linked to Coronary Disease [J].
Akhi, R. ;
Wang, C. ;
Nissinen, A. E. ;
Kankaanpaa, J. ;
Bloigu, R. ;
Paju, S. ;
Mantyla, P. ;
Buhlin, K. ;
Sinisalo, J. ;
Pussinen, P. J. ;
Horkko, S. .
JOURNAL OF DENTAL RESEARCH, 2019, 98 (03) :296-303
[8]   Salivary IgA antibody to malondialdehyde-acetaldehyde associates with mild periodontal pocket depth [J].
Akhi, Ramin ;
Nissinen, Antti E. ;
Wang, Chunguang ;
Kyrklund, Mikael ;
Paju, Susanna ;
Mantyla, Paivi ;
Buhlin, Kare ;
Sinisalo, Juha ;
Pussinen, Pirkko J. ;
Horkko, Sohvi .
ORAL DISEASES, 2022, 28 (08) :2285-2293
[9]   Matrix attachment regulates Fas-induced apoptosis in endothelial cells: A role for c-Flip and implications for anoikis [J].
Aoudjit, F ;
Vuori, K .
JOURNAL OF CELL BIOLOGY, 2001, 152 (03) :633-643
[10]  
Ardila CM, 2015, QUINTESSENCE INT, V46, P207, DOI [10.3290/j.qi.a32920, 10.3290/j.qi.032920]