Near-Infrared Photodynamic Chemiluminescent Probes for Cancer Therapy and Metastasis Detection

被引：53

作者：

Huang, Jingsheng ^{[1
]}

Zhang, Chi ^{[1
]}

Wang, Xinzhu ^{[1
]}

Wei, Xin ^{[1
]}

Pu, Kanyi ^{[1
,2
]}

机构：

[1] Nanyang Technol Univ, Sch Chem Chem Engn & Biotechnol, Singapore 637457, Singapore

[2] Lee Kong Chian Sch Med, Singapore 636921, Singapore

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2023年 / 62卷 / 24期

基金：

新加坡国家研究基金会;

关键词：

Bioimaging; Chemiluminescent Probe; Metastasis Imaging; Photodynamic Therapy; AGGREGATION-INDUCED EMISSION; LYSYL OXIDASE; PHOTOSENSITIZER; CHALLENGES; ACID;

D O I：

10.1002/anie.202303982

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

There is growing interest in the development of chemiluminescence (CL) probes for phototheranostics because of their minimized tissue autofluorescence. However, due to a lack of near-infrared (NIR)-absorbing chemiluminophores, current probes for NIR CL-guided phototherapy are based on nanoparticles made up of multiple components. We report bright unimolecular chemiluminophores with NIR absorptions and emissions, long CL half-lives and ideal photodynamic efficiency. One luminophore is modified into an activatable probe, DBPOL, with a turn-on CL signal and photodynamic activity that are specific to a cancer biomarker. The highly sensitive DBPOL allows CL-guided photodynamic therapy which completely inhibits tumor growth and lung metastasis in mouse models, and can be applied for noninvasive monitoring of lung metastasis. We provide molecular guidelines for NIR-absorbing CL probes for imaging-guided phototherapy.

引用

页数：7

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