Gradients of neurotransmitter receptor expression in the macaque cortex

被引:26
作者
Froudist-Walsh, Sean [1 ,2 ]
Xu, Ting [3 ]
Niu, Meiqi [4 ]
Rapan, Lucija [4 ]
Zhao, Ling [4 ]
Margulies, Daniel S. S. [5 ]
Zilles, Karl
Wang, Xiao-Jing [2 ]
Palomero-Gallagher, Nicola [4 ,6 ]
机构
[1] Univ Bristol, Fac Engn, Computat Neurosci Unit, Bristol, England
[2] NYU, Ctr Neural Sci, New York, NY USA
[3] Child Mind Inst, New York, NY USA
[4] Res Ctr Julich, Inst Neurosci & Med INM 1, Julich, Germany
[5] Univ Paris Cite, Integrat Neurosci & Cognit Ctr, Paris, France
[6] Heinrich Heine Univ Dusseldorf, Univ Hosp Dusseldorf, Cecile & Oskar Vogt Inst Brain Res, Med Fac, Dusseldorf, Germany
基金
欧洲研究理事会; 美国国家卫生研究院; 英国生物技术与生命科学研究理事会;
关键词
PYRAMIDAL CELL; LAYER III; CORTICAL CONNECTIONS; NEURAL SYSTEMS; HUMAN BRAIN; MONKEY; SEROTONIN; ORGANIZATION; CINGULATE; NETWORK;
D O I
10.1038/s41593-023-01351-2
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Froudist-Walsh et al. reveal organizational principles of receptor densities in macaque cortex. Densities of multiple receptor types align with changes in dendritic properties, myelin and functional networks. Data are openly released to the community. Dynamics and functions of neural circuits depend on interactions mediated by receptors. Therefore, a comprehensive map of receptor organization across cortical regions is needed. In this study, we used in vitro receptor autoradiography to measure the density of 14 neurotransmitter receptor types in 109 areas of macaque cortex. We integrated the receptor data with anatomical, genetic and functional connectivity data into a common cortical space. We uncovered a principal gradient of receptor expression per neuron. This aligns with the cortical hierarchy from sensory cortex to higher cognitive areas. A second gradient, driven by serotonin 5-HT1A receptors, peaks in the anterior cingulate, default mode and salience networks. We found a similar pattern of 5-HT1A expression in the human brain. Thus, the macaque may be a promising translational model of serotonergic processing and disorders. The receptor gradients may enable rapid, reliable information processing in sensory cortical areas and slow, flexible integration in higher cognitive areas.
引用
收藏
页码:1281 / +
页数:22
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