The Crucial Roles and Research Advances of cGAS-STING Pathway in Cutaneous Disorders

被引：5

作者：

Huang, Cong ^{[1
]}

Li, Wenting ^{[1
]}

Ren, Xuanyao ^{[2
]}

Tang, Mindan ^{[2
]}

Zhang, Kaoyuan ^{[2
]}

Zhuo, Fan ^{[1
]}

Dou, Xia ^{[1
]}

Yu, Bo ^{[1
]}

机构：

[1] Hong Kong Univ Sci & Technol, Shenzhen Peking Univ, Dept Dermatol, Skin Res Inst,Peking Univ Shenzhen Hosp,Med Ctr, Shenzhen 518036, Peoples R China

[2] Hong Kong Univ Sci & Technol, Shenzhen Peking Univ, Biomed Res Inst, Med Ctr, Shenzhen 518036, Peoples R China

来源：

INFLAMMATION | 2023年 / 46卷 / 04期

基金：

中国国家自然科学基金;

关键词：

cGAS-STING signaling; skin diseases; melanoma; molecular drugs; CYCLIC GMP-AMP; DOUBLE-STRANDED DNA; CANCER-IMMUNOTHERAPY; ANTITUMOR IMMUNITY; GLOBAL BURDEN; SKIN-DISEASE; DI-GMP; ACTIVATION; MELANOMA; LIGAND;

D O I：

10.1007/s10753-023-01812-7

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

-The cGAS-STING signaling pathway senses the presence of cytosolic DNA, induces strong type I interferon responses, and enhances inflammatory cytokine production, placing it as an important axis in infection, autoimmunity, and tumor immunity. Recent studies have shown that the abnormalities and/or dysfunctions of cGAS-STING signaling are closely related to the pathogenesis of skin diseases and/or cancers. Additionally, a variety of new therapeutics targeting the cGAS-STING signaling are in development for the treatment of skin disorders. However, the precise molecular mechanisms of cGAS-STING-mediated cutaneous disorders have not been fully elucidated. In this review, we will summarize the regulatory roles and mechanisms of cGAS-STING signaling in skin disorders and recent progresses of cGAS-STING-related drugs as well as their potential clinical applications.

引用

页码：1161 / 1176

页数：16

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