Research Advances Through Activity-Based Lipid Hydrolase Profiling

被引：1

作者：

Honeder, Sophie Elisabeth ^{[1
]}

Tomin, Tamara ^{[2
]}

Schinagl, Maximilian ^{[2
]}

Pfleger, Raphael ^{[2
]}

Hoehlschen, Julia ^{[2
]}

Darnhofer, Barbara ^{[3
]}

Schittmayer, Matthias ^{[2
]}

Birner-Gruenberger, Ruth ^{[1
,2
]}

机构：

[1] Med Univ Graz, Res & Diagnost Inst Pathol, Stiftingtalstr 6, A-8036 Graz, Austria

[2] Univ Technol Vienna, Inst Chem Technol & Analyt, Getreidemarkt 9, A-1060 Vienna, Austria

[3] Med Univ Graz, Ctr Med Res, Core Facil Mass Spectrometry, Neue Stiftingtalstr 24, A-8036 Graz, Austria

来源：

ISRAEL JOURNAL OF CHEMISTRY | 2023年 / 63卷 / 3-4期

基金：

奥地利科学基金会;

关键词：

ABPP; functional proteomics; lipid hydrolase; serine hydrolase; ACTIVITY-BASED PROBES; HIGHLY SELECTIVE INHIBITORS; ACTIVITY-BASED PROTEOMICS; ACID AMIDE HYDROLASE; SERINE HYDROLASES; DIACYLGLYCEROL LIPASE; PROTEIN; ENZYMES; LIPOLYSIS; IDENTIFICATION;

D O I：

10.1002/ijch.202200078

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Activity-based proteomic profiling (ABPP) enables the functional study of enzymes by employing small molecule probes that bind covalently to the active site of an enzyme. Activity-based probes can penetrate cells and tissues and thereby allow enzymes to be targeted/labelled in their native state. Probes can be designed to target individual enzymes or whole enzyme groups, which makes ABPP a versatile protein profiling technique. In this review, we give an overview of research advances through ABPP in the context of lipid hydrolase research. We report of lipid hydrolases that were discovered and characterized through ABPP, and aim to give an overview of commonly used probes as well as inhibitors that were discovered and characterized by competitive ABPP. Lastly, this review aims to raise caveats and current limitations of this protein profiling technique.

引用

页数：12

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