Diffusion-Weighted Imaging of the Abdomen: Correction for Gradient Nonlinearity Bias in Apparent Diffusion Coefficient

Background Gradient nonlinearity (GNL) introduces spatial nonuniformity bias in apparent diffusion coefficient (ADC) measurements, especially at large offsets from the magnet isocenter. Purpose To investigate the effects of GNL in abdominal ADC measurements and to develop an ADC bias correction procedure. Study Type Retrospective. Phantom/Population Two homemade ultrapure water phantoms/25 patients with histologically confirmed pancreatic ductal adenocarcinoma (PDAC). Field Strength/Sequence A 3.0 T/diffusion-weighted imaging (DWI) with single-shot echo-planar imaging sequence. Assessment ADC bias was computed in the three orthogonal directions at different offset locations. The spatial-dependent correctors of ADC bias were generated from the ADCs of phantom 1. The ADCs were estimated before and after corrections for the phantom 1 with both the proposed approach and the theoretical GNL correction method. For the patients, ADCs were measured in abdominal tissues including left and right liver lobes, PDAC, spleen, bilateral kidneys, and bilateral paraspinal muscles. Statistical Test Friedman tests and Wilcoxon tests. Results The ADC bias measured by phantom 1 was 9.7% and 12.6% higher in the right-left and anterior-posterior directions and 9.2% lower in the superior-inferior direction at the 150 mm offsets from the magnetic isocenter. The corrected vs. the uncorrected ADCs measurements (median: 2.20 x 10(-3) mm(2)/sec for both the proposed method and the theoretical GNL method vs. 2.31 x 10(-3) mm(2)/sec, respectively) and their relative ADC errors (0.014, 0.016, and 0.054, respectively) were lower in the phantom 1. The relative ADC errors substantially decreased after correction in the phantom 2 (median: 0.048 and -0.008, respectively). The ADCs of all the abdominal tissues were lower after correction except for the left liver lobes (P = 0.13). Data Conclusion GNL bias in abdominal ADC can be measured by a DWI phantom. The proposed correction procedure was successfully applied for the bias correction in abdominal ADC. Evidence Level 3. Technical Efficacy Stage 1.