The peptide link between pathogens and human centromere proteins

被引：0

作者：

Huang, Zhuowei ^{[1
,2
]}

Liang, Yingjie ^{[1
,2
]}

Liu, Xiaolan ^{[1
,2
]}

机构：

[1] Wuhan Mental Hlth Ctr, Dept Psychiat, Wuhan, Peoples R China

[2] Wuhan Hosp Psychotherapy, Dept Tradit Chinese Integrated Western Med, Wuhan, Peoples R China

来源：

SCANDINAVIAN JOURNAL OF IMMUNOLOGY | 2023年 / 97卷 / 02期

基金：

中国国家自然科学基金;

关键词：

autoimmune diseases; centromere proteins; human pathogens; peptide match; SYSTEMIC-SCLEROSIS; CENP-A; ANTICENTROMERE ANTIBODIES; CYTOMEGALOVIRUS; AUTOANTIBODIES; AUTOANTIGEN; SCLERODERMA; DISEASE; TYPE-1;

D O I：

10.1111/sji.13231

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

This work tested the hypothesis that infection causes unexplained production of anti-centromere protein antibodies (ACA) via autoimmune cross-reactivity. To further examine the clinical origin of ACA, the overlapped peptides between human pathogens, including viruses, bacteria and fungi and centromere proteins (CENP-A, CENP-B and CENP-C) were assessed. We found a broad overlap of pathogenetic peptides with human centromere proteins. These data indicate potential immune cross-reactivity between pathogens and human centromere proteins. Additionally, the current findings corroborate a molecular and mechanistic framework for autoimmune disorders related to infection. Moreover, preliminary evidence for a potential role of infection in ACA-related autoimmune diseases was presented.

引用

页数：9

共 43 条

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