Long-term in vivo dissolution of thermo- and pH-responsive, 19F magnetic resonance-traceable and injectable polymer implants

被引：3

作者：

Jirat-Ziolkowska, Natalia ^{[1
,2
]}

Vit, Martin ^{[1
]}

Groborz, Ondrej ^{[2
,3
]}

Kolouchova, Kristyna ^{[3
]}

Cerveny, David ^{[1
,4
]}

Sedlacek, Ondrej ^{[5
]}

Jirak, Daniel ^{[1
,4
]}

机构：

[1] Inst Clin & Expt Med, Radiodiagnost & Intervent Radiol Dept, Videnska 1958-9, Prague 14021, Czech Republic

[2] Charles Univ Prague, Inst Biophys & Informat, Fac Med 1, Katerinska 1660-32, Prague 12108, Czech Republic

[3] Czech Acad Sci, Inst Macromol Chem, Heyrovsky Sq 2, Prague 16206, Czech Republic

[4] Tech Univ Liberec, Fac Hlth Studies, Studentska 1402-2, Liberec 46117 1, Czech Republic

[5] Charles Univ Prague, Fac Sci, Dept Phys & Macromol Chem, Hlavova 8, Prague 12800, Czech Republic

来源：

NANOSCALE ADVANCES | 2024年 / 6卷 / 12期

关键词：

ECM HYDROGEL; THERAPY; NANOPARTICLES; AGENT;

D O I：

10.1039/d4na00212a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

F-19 magnetic resonance (F-19 MR) tracers stand out for their wide range of applications in experimental and clinical medicine, as they can be precisely located in living tissues with negligible fluorine background. This contribution demonstrates the long-term dissolution of multiresponsive fluorinated implants designed for prolonged release. Implants were detected for 14 (intramuscular injection) and 20 (subcutaneous injection) months by F-19 MR at 4.7 T, showing favorable MR relaxation times, biochemical stability, biological compatibility and slow, long-term dissolution. Thus, polymeric implants may become a platform for long-term local theranostics.

引用

页码：3041 / 3051

页数：11

共 2 条

[1] Novel 19F MRS/I Nanoprobe Based on pH-Responsive PEGylated Nanogel: pH-Dependent 19F Magnetic Resonance Studies
Oishi, Motoi
Sumitani, Shogo
Bronich, Tatiana K.
Kabanov, Alexander V.
Boska, Michael D.
Nagasaki, Yukio
CHEMISTRY LETTERS, 2009, 38 (02) : 128 - 129
[2] A New Thermo-, pH- and CO2-Responsive Fluorescent Four-Arm Star Polymer with Aggregation-Induced Emission for Long-Term Cellular Tracing
Guan, Xiaolin
Meng, Li
Jin, Qijun
Lu, Baocui
Chen, Yanbin
Li, Zhifei
Wang, Lin
Lai, Shoujun
Lei, Ziqiang
MACROMOLECULAR MATERIALS AND ENGINEERING, 2018, 303 (06)

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