Amperometric Method for Detecting Paracetamol using a Carbon Paste Electrode Modified with Vanadium(V) Oxide

被引：3
作者：
Nagles, Edgar [1 ]
Cardenas-Riojas, Andy A. [2 ]
Anaya-Roa, Fernando [1 ]
Roldan-Tello, Luz [1 ]
Hurtado, John J. [3 ]
机构：
[1] Univ Nacl Mayor San Marcos, Fac Quim & Ing Quim, Lima 15081, Peru
[2] Univ Nacl Ingn, Fac Ciencias, Lab Electroquim Aplicada, Ave Tupac Amaru 210, Rimac 15333, Lima, Peru
[3] Univ Los Andes, Dept Quim, Bogota 111711, Colombia
来源：
CHEMISTRYSELECT | 2024年 / 9卷 / 06期
关键词：
Paracetamol; vanadium oxide (V); Carbon paste; Modified electrode; ELECTROCHEMICAL DETERMINATION; ACETAMINOPHEN; NANOPARTICLES;
D O I：
10.1002/slct.202304770
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
This new and simple amperometric method takes advantage of the electroactivity of V2O5 in the oxidation of paracetamol (PCM) on a carbon paste electrode (CPE). With the modified electrode (VOX/CPE) the anode peak current for PCM was more than 100 % than that of the unmodified electrode. The electrode surface was characterized by cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS) and scanning electron microscopy (SEM). The amperograms were measured at +0.70 V (vs Ag/AgCl), and the calibration curve indicated a detection limit of 0.06 mu mol/L and a sensitivity of 1.93 mu A/mu M cm2. The modified electrode was used in the detection of solid drugs such as PCM tablets and children's syrup with acceptable results. A novel amperometric method is reported for the detection of paracetamol using a carbon paste decorated with vanadium oxide. This method provided a detection limit less than 1.0 mu mol/L. The results for this new method are interesting due to its potential for application in the pharmaceutical industry. image
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页数：8
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