Advance and Challenges in the Treatment of Skin Diseases with the Transdermal Drug Delivery System

被引:36
作者
Cheng, Tingting [1 ,2 ]
Tai, Zongguang [2 ]
Shen, Min [2 ]
Li, Ying [2 ]
Yu, Junxia [1 ,2 ]
Wang, Jiandong [1 ,2 ]
Zhu, Quangang [2 ]
Chen, Zhongjian [1 ,2 ]
机构
[1] Bengbu Med Coll, Sch Pharm, 2600 Donghai Rd, Bengbu 233030, Peoples R China
[2] Tongji Univ, Shanghai Skin Dis Hosp, Sch Med, 1278 Baode Rd, Shanghai 200443, Peoples R China
基金
中国国家自然科学基金;
关键词
advance; bioequivalence; challenge; skin disease; transdermal drug delivery system; SOLID LIPID NANOPARTICLES; MICELLAR NANOCARRIERS; MICRONEEDLE PATCHES; CUTANEOUS DELIVERY; POLYMERIC MICELLES; BENZOYL PEROXIDE; BARRIER FUNCTION; DERMAL DELIVERY; CYCLOSPORINE-A; IN-VIVO;
D O I
10.3390/pharmaceutics15082165
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Skin diseases are among the most prevalent non-fatal conditions worldwide. The transdermal drug delivery system (TDDS) has emerged as a promising approach for treating skin diseases, owing to its numerous advantages such as high bioavailability, low systemic toxicity, and improved patient compliance. However, the effectiveness of the TDDS is hindered by several factors, including the barrier properties of the stratum corneum, the nature of the drug and carrier, and delivery conditions. In this paper, we provide an overview of the development of the TDDS from first-generation to fourth-generation systems, highlighting the characteristics of each carrier in terms of mechanism composition, penetration method, mechanism of action, and recent preclinical studies. We further investigated the significant challenges encountered in the development of the TDDS and the crucial significance of clinical trials.
引用
收藏
页数:23
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共 145 条
[51]   Hyaluronic acid functionalization improves dermal targeting of polymeric nanoparticles for management of burn wounds: In vitro, ex vivo and in vivo evaluations [J].
Hussain, Zahid ;
Pandey, Manisha ;
Thu, Hnin Ei ;
Kaur, Taasjir ;
Jia, Gan Wei ;
Ying, Pang Cheau ;
Xian, Tan Mei ;
Abourehab, Mohammad A. S. .
BIOMEDICINE & PHARMACOTHERAPY, 2022, 150
[52]   Transdermal iontophoretic drug delivery: advances and challenges [J].
Ita, Kevin .
JOURNAL OF DRUG TARGETING, 2016, 24 (05) :386-391
[53]   Prodrugs for transdermal drug delivery - trends and challenges [J].
Ita, Kevin B. .
JOURNAL OF DRUG TARGETING, 2016, 24 (08) :671-678
[54]   Comparative assessment of efficacy and safety potential of multifarious lipid based Tacrolimus loaded nanoformulations [J].
Jain, Sanyog ;
Addan, Ramu ;
Kushwah, Varun ;
Harde, Harshad ;
Mahajan, Rahul R. .
INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2019, 562 :96-104
[55]   Codelivery of benzoyl peroxide & adapalene using modified liposomal gel for improved acne therapy [J].
Jain, Sanyog ;
Kale, Dnyaneshwar P. ;
Swami, Rajan ;
Katiyar, Sameer S. .
NANOMEDICINE, 2018, 13 (12) :1481-1493
[56]   High-Dose Steroid Dissolving Microneedle for Relieving Atopic Dermatitis [J].
Jang, Mingyu ;
Kang, Bo Mi ;
Yang, Huisuk ;
Ohn, Jungyoon ;
Kwon, Ohsang ;
Jung, Hyungil .
ADVANCED HEALTHCARE MATERIALS, 2021, 10 (07)
[57]   γδ T cells and inflammatory skin diseases [J].
Jee, Mia Hamilton ;
Mraz, Veronika ;
Geisler, Carsten ;
Bonefeld, Charlotte Menne .
IMMUNOLOGICAL REVIEWS, 2020, 298 (01) :61-73
[58]   Local dermal delivery of cyclosporin A, a hydrophobic and high molecular weight drug, using dissolving microneedles [J].
Jeong, Hye-Rin ;
Kim, Ji-Yeon ;
Kim, Sang-Nyun ;
Park, Jung-Hwan .
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, 2018, 127 :237-243
[59]   Nanoscale systems for local drug delivery [J].
Ji, Tianjiao ;
Kohane, Daniel S. .
NANO TODAY, 2019, 28
[60]   Polymeric micellar nanocarriers of benzoyl peroxide as potential follicular targeting approach for acne treatment [J].
Kahraman, Emine ;
Ozhan, Gul ;
Ozsoy, Yildiz ;
Gungor, Sevgi .
COLLOIDS AND SURFACES B-BIOINTERFACES, 2016, 146 :692-699