共 145 条
Advance and Challenges in the Treatment of Skin Diseases with the Transdermal Drug Delivery System
被引:36
作者:

Cheng, Tingting
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机构:
Bengbu Med Coll, Sch Pharm, 2600 Donghai Rd, Bengbu 233030, Peoples R China
Tongji Univ, Shanghai Skin Dis Hosp, Sch Med, 1278 Baode Rd, Shanghai 200443, Peoples R China Bengbu Med Coll, Sch Pharm, 2600 Donghai Rd, Bengbu 233030, Peoples R China

Tai, Zongguang
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h-index: 0
机构:
Tongji Univ, Shanghai Skin Dis Hosp, Sch Med, 1278 Baode Rd, Shanghai 200443, Peoples R China Bengbu Med Coll, Sch Pharm, 2600 Donghai Rd, Bengbu 233030, Peoples R China

Shen, Min
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机构:
Tongji Univ, Shanghai Skin Dis Hosp, Sch Med, 1278 Baode Rd, Shanghai 200443, Peoples R China Bengbu Med Coll, Sch Pharm, 2600 Donghai Rd, Bengbu 233030, Peoples R China

Li, Ying
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机构:
Tongji Univ, Shanghai Skin Dis Hosp, Sch Med, 1278 Baode Rd, Shanghai 200443, Peoples R China Bengbu Med Coll, Sch Pharm, 2600 Donghai Rd, Bengbu 233030, Peoples R China

Yu, Junxia
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机构:
Bengbu Med Coll, Sch Pharm, 2600 Donghai Rd, Bengbu 233030, Peoples R China
Tongji Univ, Shanghai Skin Dis Hosp, Sch Med, 1278 Baode Rd, Shanghai 200443, Peoples R China Bengbu Med Coll, Sch Pharm, 2600 Donghai Rd, Bengbu 233030, Peoples R China

Wang, Jiandong
论文数: 0 引用数: 0
h-index: 0
机构:
Bengbu Med Coll, Sch Pharm, 2600 Donghai Rd, Bengbu 233030, Peoples R China
Tongji Univ, Shanghai Skin Dis Hosp, Sch Med, 1278 Baode Rd, Shanghai 200443, Peoples R China Bengbu Med Coll, Sch Pharm, 2600 Donghai Rd, Bengbu 233030, Peoples R China

Zhu, Quangang
论文数: 0 引用数: 0
h-index: 0
机构:
Tongji Univ, Shanghai Skin Dis Hosp, Sch Med, 1278 Baode Rd, Shanghai 200443, Peoples R China Bengbu Med Coll, Sch Pharm, 2600 Donghai Rd, Bengbu 233030, Peoples R China

Chen, Zhongjian
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h-index: 0
机构:
Bengbu Med Coll, Sch Pharm, 2600 Donghai Rd, Bengbu 233030, Peoples R China
Tongji Univ, Shanghai Skin Dis Hosp, Sch Med, 1278 Baode Rd, Shanghai 200443, Peoples R China Bengbu Med Coll, Sch Pharm, 2600 Donghai Rd, Bengbu 233030, Peoples R China
机构:
[1] Bengbu Med Coll, Sch Pharm, 2600 Donghai Rd, Bengbu 233030, Peoples R China
[2] Tongji Univ, Shanghai Skin Dis Hosp, Sch Med, 1278 Baode Rd, Shanghai 200443, Peoples R China
基金:
中国国家自然科学基金;
关键词:
advance;
bioequivalence;
challenge;
skin disease;
transdermal drug delivery system;
SOLID LIPID NANOPARTICLES;
MICELLAR NANOCARRIERS;
MICRONEEDLE PATCHES;
CUTANEOUS DELIVERY;
POLYMERIC MICELLES;
BENZOYL PEROXIDE;
BARRIER FUNCTION;
DERMAL DELIVERY;
CYCLOSPORINE-A;
IN-VIVO;
D O I:
10.3390/pharmaceutics15082165
中图分类号:
R9 [药学];
学科分类号:
1007 ;
摘要:
Skin diseases are among the most prevalent non-fatal conditions worldwide. The transdermal drug delivery system (TDDS) has emerged as a promising approach for treating skin diseases, owing to its numerous advantages such as high bioavailability, low systemic toxicity, and improved patient compliance. However, the effectiveness of the TDDS is hindered by several factors, including the barrier properties of the stratum corneum, the nature of the drug and carrier, and delivery conditions. In this paper, we provide an overview of the development of the TDDS from first-generation to fourth-generation systems, highlighting the characteristics of each carrier in terms of mechanism composition, penetration method, mechanism of action, and recent preclinical studies. We further investigated the significant challenges encountered in the development of the TDDS and the crucial significance of clinical trials.
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