Safety, Tolerability, Pharmacokinetics (PK), and Pharmacodynamics (PD) of a Dual GLP-1/GIP Receptor Agonist (HRS9531) in Healthy Subjects-A Phase 1, Randomized, Double-Blind, Placebo-Controlled, Single and Multiple Ascending Dose (SAD and MAD) Study

被引：2
|
作者：
He, Kun
Wei, Fang
Chen, Hong
Zhang, Yanyan
Sheng, Zhen
Wen, Qing
机构：
来源：
DIABETES | 2023年 / 72卷
关键词：
D O I：
10.2337/db23-763-P
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
763-P
引用
收藏
页数：2
相关论文
共 50 条
  • [21] Safety, tolerability, and pharmacokinetics of oral baicalein tablets in healthy Chinese subjects: A single-center, randomized, double-blind, placebo-controlled multiple-ascending-dose study
    Li, Lijun
    Gao, Hongzhi
    Lou, Kun
    Luo, Hongmei
    Hao, Sheng
    Yuan, Jing
    Liu, Zeyuan
    Dong, Ruihua
    CTS-CLINICAL AND TRANSLATIONAL SCIENCE, 2021, 14 (05): : 2017 - 2024
  • [22] Pharmacodynamics, Pharmacokinetics, Safety, and Tolerability of the Novel Dual GIP/GLP-1 Agonist (RG7697) after Single Subcutaneous Administration in Healthy Subjects
    Portron, Agnes
    Jadidi, Shirin
    Sarkar, Neena
    Dimarchi, Richard
    Schmitt, Christophe
    DIABETES, 2017, 66 : A624 - A624
  • [23] A randomized, double-blinded, placebo-controlled single ascending dose study to assess safety, tolerability, immunogenicity, and pharmacokinetics of a novel long-acting GLP-1/GIP/glucagon triple agonist (hm15211) in healthy obese subjects
    Choi, JaeDuk
    Kim, Youngmin
    Eun, Kahee
    Morrow, Linda
    Hompesch, Marcus
    Baek, Seungjae
    JOURNAL OF HEPATOLOGY, 2020, 73 : S455 - S456
  • [24] Safety, tolerability, and pharmacokinetics of HRS9432(A) injection in healthy Chinese subjects: a phase-I randomized, double-blind, dose escalation, placebo-controlled study
    Yan, Xin
    Huang, Yuanyuan
    Xie, Jinlian
    Wu, Qian
    Yang, Shuang
    Yang, Xiaoyan
    Chen, Honghui
    Huang, Jie
    Yang, Guoping
    ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2024, 68 (07) : e0052424
  • [25] Correction to: A Phase I, Randomized, Double-Blind, Placebo-Controlled, Single Ascending Dose, Multiple Dose, and Food Effect Trial of the Safety, Tolerability and Pharmacokinetics of Highly Purified Cannabidiol in Healthy Subjects
    Lesley Taylor
    Barry Gidal
    Graham Blakey
    Bola Tayo
    Gilmour Morrison
    CNS Drugs, 2019, 33 : 397 - 397
  • [26] The safety, tolerability, pharmacokinetics and pharmacodynamics of an optimized dual GLP-1/GIP receptor agonist (BGM0504) in healthy volunteers: A dose-escalation Phase I study
    Fan, Yuxin
    Yuan, Jiandong
    Dong, Lichun
    Yu, Chongjing
    Ding, Haifeng
    Xie, Daosheng
    Guan, Runfang
    Li, Ruixia
    Zou, Wenhong
    Long, Shuxian
    Chen, Jion
    Huang, Yu
    Yang, Mei
    He, Jianchang
    Wen, Weibo
    DIABETES OBESITY & METABOLISM, 2025, 27 (04): : 2110 - 2119
  • [27] A Phase 1, Single-Center, Randomized, Double-Blind, Placebo-Controlled, Single Ascending Dose Study to Investigate the Safety, Tolerability, and Pharmacokinetics of Intravenous and Subcutaneous Garadacimab (CSL312) in Healthy Subjects
    McKenzie, Andrew
    Roberts, Anthony
    Malandkar, Sourabh
    Feuersenger, Henrike
    Panousis, Con
    Pawaskar, Dipti
    JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2021, 147 (02) : AB137 - AB137
  • [28] Phase 1, Randomized, Double-Blind, Placebo-Controlled Studies of the Safety, Tolerability and Pharmacokinetics of Naldemedine in Healthy Volunteers
    Fukumura, Kazuya
    Yokota, Takaaki
    Baba, Yuko
    Camilo, Juan
    Ferreira, Arjona
    GASTROENTEROLOGY, 2016, 150 (04) : S537 - S538
  • [29] Phase 1, Randomized, Double-Blind, Placebo-Controlled Studies on the Safety, Tolerability, and Pharmacokinetics of Naldemedine in Healthy Volunteers
    Fukumura, Kazuya
    Yokota, Takaaki
    Baba, Yuko
    Ferreira, Juan Camilo Arjona
    CLINICAL PHARMACOLOGY IN DRUG DEVELOPMENT, 2018, 7 (05): : 474 - 483
  • [30] PHASE 1, RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED, SINGLE- AND MULTIPLE-ASCENDING DOSE STUDY OF THE SAFETY, TOLERABILITY AND PHARMACOKINETICS OF THE ASK1 INHIBITOR SRT-015 IN HEALTHY ADULTS
    Burge, Daniel J.
    Elias, Kathleen
    Plonowski, Artur
    Porter, Terence
    McDonnell, Neil
    HEPATOLOGY, 2022, 76 : S97 - S97
12345