Correlating Receptor Status with Nottingham Prognostic Index in Breast Cancer

被引：0
|
作者：
Gupta, Rohan [1 ]
Khanna, Rahul [1 ]
Kar, Amrita G. [2 ]
Khanna, Seema [1 ]
Khanna, Siddharth [3 ]
Meena, Ram Niwas [1 ]
机构：
[1] Banaras Hindu Univ, Inst Med Sci, Dept Surg, Varanasi 221005, India
[2] Banaras Hindu Univ, Inst Med Sci, Dept Pathol, Varanasi 221005, India
[3] Aligarh Muslim Univ, Dept Ophthalmol, Aligarh 202002, India
来源：
INDIAN JOURNAL OF SURGERY | 2024年 / 86卷 / 02期
关键词：
Breast cancer; Nottingham Prognostic Index; Receptor status;
D O I：
10.1007/s12262-023-03865-2
中图分类号：
R61 [外科手术学];
学科分类号：
摘要：
The biological behavior and prognosis of breast cancer is often unpredictable with a number of factors contributing to the outcome. Nottingham's Prognostic Factor (NPI) takes into account the tumor size, nodal status, and histological grade of tumor. The receptor status considers the hormone receptor and HER2 status. The aim of the study was to correlate the NPI score with the receptor status expression in Indian women with breast cancer. A total of 78 breast cancer patients who underwent upfront modified radical mastectomy were recruited. NPI score and receptor status assessment was done at histopathological examination of the specimen. Hormone receptor negative breast cancer tended to have a higher NPI score compared to hormone receptor positive patients. However, this difference did not achieve statistical significance. NPI score parameters except for the histological grade are a reflection of the duration or time span of the tumor. On the contrary, the receptor status is indicative of the tumor biology and not of its time duration. A scoring system which incorporates the three parameters of the NPI as well as the receptor status would be the best prognostic index as well as predictive regarding the choice of adjuvant therapy.
引用
收藏
页码：344 / 347
页数：4
相关论文
共 50 条
  • [1] Applying the Nottingham Prognostic Index to a Swedish breast cancer population
    Marie Sundquist
    Sten Thorstenson
    Lars Brudin
    Bo Nordenskjöld
    Breast Cancer Research and Treatment, 1999, 53 : 1 - 8
  • [2] Applying the Nottingham Prognostic Index to a Swedish breast cancer population
    Sundquist, M
    Thorstenson, S
    Brudin, L
    Nordenskjöld, B
    BREAST CANCER RESEARCH AND TREATMENT, 1999, 53 (01) : 1 - 8
  • [3] The prognostic performance of Adjuvant! Online and Nottingham Prognostic Index in young breast cancer patients
    Lambertini, Matteo
    Pinto, Ana Catarina
    Ameye, Lieveke
    Jongen, Lynn
    Del Mastro, Lucia
    Puglisi, Fabio
    Poggio, Francesca
    Bonotto, Marta
    Floris, Giuseppe
    Van Asten, Kathleen
    Wildiers, Hans
    Neven, Patrick
    de Azambuja, Evandro
    Paesmans, Marianne
    Azim, Hatem A., Jr.
    BRITISH JOURNAL OF CANCER, 2016, 115 (12) : 1471 - 1478
  • [4] Nottingham Prognostic Index in Triple-Negative Breast Cancer: a reliable prognostic tool?
    André Albergaria
    Sara Ricardo
    Fernanda Milanezi
    Vítor Carneiro
    Isabel Amendoeira
    Daniella Vieira
    Jorge Cameselle-Teijeiro
    Fernando Schmitt
    BMC Cancer, 11
  • [5] The prognostic performance of Adjuvant! Online and Nottingham Prognostic Index in young breast cancer patients
    Matteo Lambertini
    Ana Catarina Pinto
    Lieveke Ameye
    Lynn Jongen
    Lucia Del Mastro
    Fabio Puglisi
    Francesca Poggio
    Marta Bonotto
    Giuseppe Floris
    Kathleen Van Asten
    Hans Wildiers
    Patrick Neven
    Evandro de Azambuja
    Marianne Paesmans
    Hatem A Azim Jr
    British Journal of Cancer, 2016, 115 : 1471 - 1478
  • [6] Is Nottingham prognostic index useful after induction chemotherapy in operable breast cancer?
    Chollet, P
    Amat, S
    Belembaogo, E
    Curé, H
    de Latour, M
    Dauplat, J
    Le Bouëdec, G
    Mouret-Raynier, MA
    Ferrière, JP
    Penault-Llorca, F
    BRITISH JOURNAL OF CANCER, 2003, 89 (07) : 1185 - 1191
  • [7] Is Nottingham prognostic index useful after induction chemotherapy in operable breast cancer?
    P Chollet
    S Amat
    E Belembaogo
    H Curé
    M de Latour
    J Dauplat
    G Le Bouëdec
    M-A Mouret-Reynier
    J-P Ferrière
    F Penault-Llorca
    British Journal of Cancer, 2003, 89 : 1185 - 1191
  • [8] Correlation analysis between molecular subtypes and Nottingham Prognostic Index in breast cancer
    Zhen, Hongchao
    Yang, Liuting
    Li, Li
    Yu, Junxian
    Zhao, Lei
    Li, Yingying
    Li, Qin
    ONCOTARGET, 2017, 8 (43) : 74096 - 74105
  • [9] The prognostic contribution of estrogen and progesterone receptor status to a modified version of the Nottingham Prognostic Index
    K. Collett
    R. Skjærven
    B.O. Mæhle
    Breast Cancer Research and Treatment, 1998, 48 : 1 - 9
  • [10] The prognostic contribution of estrogen and progesterone receptor status to a modified version of the Nottingham Prognostic Index
    Collett, K
    Skjærven, R
    Mæhle, BO
    BREAST CANCER RESEARCH AND TREATMENT, 1998, 48 (01) : 1 - 9
12345