Gene Expression Analysis in Postmortem Brains from Individuals Who Died by Suicide: A Systematic Review

被引:3
作者
Gonzalez-Castro, Thelma Beatriz [1 ]
Genis-Mendoza, Alma Delia [2 ,3 ]
Lopez-Narvaez, Maria Lilia [4 ]
Juarez-Rojop, Isela Esther [5 ]
Ramos-Mendez, Miguel Angel [5 ]
Tovilla-Zarate, Carlos Alfonso [5 ]
Nicolini, Humberto [2 ]
机构
[1] Univ Juarez Autonoma Tabasco, Div Acad Multidisciplinaria Jalpa de Mendez, Jalpa de Mendez 86205, Mexico
[2] Inst Nacl Med Genom, Lab Genom Enfermedades Psiquiatr & Neurodegenerat, Ciudad de Mexico 14610, Mexico
[3] Hosp Psiquiatr Infantil Dr Juan N Navarro, Serv Atenc Psiquiatr, Ciudad de Mexico 14080, Mexico
[4] Univ Juarez Autonoma Tabasco, Div Acad Multidisciplinaria Comalcalco, Comalcalco 86650, Mexico
[5] Univ Juarez Autonoma Tabasco, Div Acad Ciencias Salud, Villahermosa 86100, Mexico
关键词
expression analysis; brains; suicide; systematic review; DORSOLATERAL PREFRONTAL CORTEX; GLUCOCORTICOID-RECEPTOR; MAJOR DEPRESSION; PROMOTER METHYLATION; NEUROTROPHIC FACTOR; ALTERED EXPRESSION; COMPLETED SUICIDE; DNA METHYLATION; VIOLENT SUICIDE; SEX-DIFFERENCES;
D O I
10.3390/brainsci13060906
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Around the world, more the 700,000 individuals die by suicide every year. It is necessary to understand the mechanisms associated with suicidal behavior. Recently, an increase in gene expression studies has been in development. Through a systematic review, we aimed to find a candidate gene in gene expression studies on postmortem brains of suicide completers. Databases were systematically searched for published studies. We performed an online search using PubMed, Scopus and Web of Science databases to search studies up until May 2023. The terms included were "gene expression", "expressed genes", "microarray", "qRT-PCR", "brain samples" and "suicide". Our systematic review included 59 studies covering the analysis of 1450 brain tissues from individuals who died by suicide. The majority of gene expression profiles were obtained of the prefrontal cortex, anterior cingulate cortex, dorsolateral prefrontal cortex, ventral prefrontal cortex and orbital frontal cortex area. The most studied mRNAs came of genes in glutamate, & gamma;-amino-butyric acid and polyamine systems. mRNAs of genes in the brain-derived neurotrophic factor, tropomyosin-related kinase B (TrkB), HPA axis and chemokine family were also studied. On the other hand, psychiatric comorbidities indicate that suicide by violent death can alter the profile of mRNA expression.
引用
收藏
页数:18
相关论文
共 80 条
  • [21] Garbett Krassimira, 2008, Neuropsychopharmacol Hung, V10, P9
  • [22] Alterations in Gene and Protein Expression of Cannabinoid CB2 and GPR55 Receptors in the Dorsolateral Prefrontal Cortex of Suicide Victims
    Garcia-Gutierrez, Maria S.
    Navarrete, Francisco
    Navarro, Gemma
    Reyes-Resina, Irene
    Franco, Rafael
    Luis Lanciego, Jose
    Giner, Salvador
    Manzanares, Jorge
    [J]. NEUROTHERAPEUTICS, 2018, 15 (03) : 796 - 806
  • [23] Brain cortical and subcortical morphology in adolescents with depression and a history of suicide attempt
    Gifuni, Anthony J.
    Chakravarty, M. Mallar
    Lepage, Martin
    Ho, Tiffany C.
    Geoffroy, Marie-Claude
    Lacourse, Eric
    Gotlib, Ian H.
    Turecki, Gustavo
    Renaud, Johanne
    Jollant, Fabrice
    [J]. JOURNAL OF PSYCHIATRY & NEUROSCIENCE, 2021, 46 (03): : E347 - E357
  • [24] Gray AL, 2015, MOL PSYCHIATR, V20, P1057, DOI 10.1038/mp.2015.91
  • [25] Effects of promoter methylation on increased expression of polyamine biosynthetic genes in suicide
    Gross, Jeffrey A.
    Fiori, Laura M.
    Labonte, Benoit
    Lopez, Juan Pablo
    Turecki, Gustavo
    [J]. JOURNAL OF PSYCHIATRIC RESEARCH, 2013, 47 (04) : 513 - 519
  • [26] Expression of corticotropin releasing hormone receptors type I and type II mRNA in suicide victims and controls
    Hiroi, N
    Wong, ML
    Licinio, J
    Park, C
    Young, M
    Gold, PW
    Chrousos, GP
    Bornstein, SR
    [J]. MOLECULAR PSYCHIATRY, 2001, 6 (05) : 540 - 546
  • [27] TrkB gene expression and DNA methylation state in Wernicke area does not associate with suicidal behavior
    Keller, Simona
    Sarchiapone, Marco
    Zarrilli, Federica
    Tomaiuolo, Rossella
    Carli, Vladimir
    Angrisano, Tiziana
    Videtic, Alja
    Amato, Felice
    Pero, Raffaela
    di Giannantonio, Massimo
    Iosue, Miriam
    Lembo, Francesca
    Castaldo, Giuseppe
    Chiariotti, Lorenzo
    [J]. JOURNAL OF AFFECTIVE DISORDERS, 2011, 135 (1-3) : 400 - 404
  • [28] Increased BDNF Promoter Methylation in the Wernicke Area of Suicide Subjects
    Keller, Simona
    Sarchiapone, Marco
    Zarrilli, Federica
    Videtic, Alja
    Ferraro, Angelo
    Carli, Vladimir
    Sacchetti, Silvana
    Lembo, Francesca
    Angiolillo, Antonella
    Jovanovic, Nikolina
    Pisanti, Francesco
    Tomaiuolo, Rossella
    Monticelli, Antonella
    Balazic, Joze
    Roy, Alec
    Marusic, Andrej
    Cocozza, Sergio
    Fusco, Alfredo
    Bruni, Carmelo B.
    Castaldo, Giuseppe
    Chiariotti, Lorenzo
    [J]. ARCHIVES OF GENERAL PSYCHIATRY, 2010, 67 (03) : 258 - 267
  • [29] Suicide candidate genes associated with bipolar disorder and schizophrenia: An exploratory gene expression profiling analysis of post-mortem prefrontal cortex
    Kim, Sanghyeon
    Choi, Kwang-Ho
    Baykiz, Ali Fuat
    Gershenfeld, Howard K.
    [J]. BMC GENOMICS, 2007, 8 (1)
  • [30] Altered expression of genes involved in ATP biosynthesis and GABAergic neurotransmission in the ventral prefrontal cortex of suicides with and without major depression
    Klempan, T. A.
    Sequeira, A.
    Canetti, L.
    Lalovic, A.
    Ernst, C.
    Ffrench-Mullen, J.
    Turecki, G.
    [J]. MOLECULAR PSYCHIATRY, 2009, 14 (02) : 175 - 189