A Rare Case of Metastasis of Gastric Adenocarcinoma to the Leptomeninges

被引:0
作者
Doshi, Krishna [1 ]
James, Edward [2 ]
机构
[1] Advocate Lutheran Gen Hosp, Internal Med, Park Ridge, IL 60068 USA
[2] Advocate Lutheran Gen Hosp, Oncol, Park Ridge, IL USA
关键词
neuroimaging; malignancy; signet ring adenocarcinoma; leptomeningeal carcinomatosis; gastric; adenocarcinoma; RETROSPECTIVE ANALYSIS; CARCINOMATOSIS; CANCER; DIAGNOSIS;
D O I
10.7759/cureus.37120
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Leptomeningeal carcinomatosis (LMC) is defined as the diffuse infiltration of malignant cells throughout the pia and arachnoid membrane. LMC is commonly observed in patients with leukemia, lymphoma, and breast and lung cancer. The prevalence of LMC spread in patients with primary gastric malignancy is very rare. Due to its devastating neurological complications and high mortality, it is difficult to assess the associated clinical features, treatment outcomes, and prognostic factors. Current treatment options include intra-thecal chemotherapy, radiotherapy, and supportive care with a median survival of three to four months. LMC is a rare manifestation of gastric cancer and is an extremely fatal disease. Therefore, it is difficult to distinguish LMC from other neurological etiologies. We present a unique case of an individual who presented with headaches and was found to have LMC.
引用
收藏
页数:5
相关论文
共 16 条
[1]   Leptomeningeal carcinomatosis of gastric adenocarcinoma [J].
Bulut, Gulcan ;
Erden, Asuman ;
Karaca, Burcak ;
Goker, Erdem .
TURKISH JOURNAL OF GASTROENTEROLOGY, 2011, 22 (02) :195-198
[2]   Current diagnosis and treatment of leptomeningeal metastasis [J].
DeAngelis, LM .
JOURNAL OF NEURO-ONCOLOGY, 1998, 38 (2-3) :245-252
[3]   Leptomeningeal carcinomatosis from gastric cancer: single institute retrospective analysis of 9 cases [J].
Kim, Nam-Hee ;
Kim, Ji-Hyun ;
Chin, Hyung-Min ;
Jun, Kyong-Hwa .
ANNALS OF SURGICAL TREATMENT AND RESEARCH, 2014, 86 (01) :16-21
[4]   Leptomeningeal Carcinomatosis of Gastric Cancer Misdiagnosed as Vestibular Schwannoma [J].
Kim, Shin-Jae ;
Kwon, Jeong-Taik ;
Mun, Seog-Kyun ;
Hong, Young-Ho .
JOURNAL OF KOREAN NEUROSURGICAL SOCIETY, 2014, 56 (01) :51-54
[5]  
KOKKORIS CP, 1983, CANCER, V51, P154, DOI 10.1002/1097-0142(19830101)51:1<154::AID-CNCR2820510130>3.0.CO
[6]  
2-K
[7]   Leptomeningeal carcinomatosis in gastric cancer [J].
Lee, JL ;
Kang, YK ;
Kim, TW ;
Chang, HM ;
Lee, GW ;
Ryu, MH ;
Kim, E ;
Oh, SJ ;
Lee, JH ;
Kim, SB ;
Kim, SW ;
Suh, C ;
Lee, KH ;
Lee, JS ;
Kim, WK ;
Kim, SH .
JOURNAL OF NEURO-ONCOLOGY, 2004, 66 (1-2) :167-174
[8]   Leptomeningeal carcinomatosis originating from gastric cancer - Report of eight cases and review of the literature [J].
Lisenko, Y ;
Kumar, AJ ;
Yao, J ;
Ajani, J ;
Ho, L .
AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS, 2003, 26 (02) :165-170
[9]   Leptomeningeal carcinomatosis from gastric cancer successfully treated by the intrathecal methotrexate plus temozolomide and simultaneous radiotherapy: Case report and literatures review [J].
Liu, Yangyang .
CANCER BIOLOGY & THERAPY, 2017, 18 (10) :761-764
[10]   Gastric leptomeningeal carcinomatosis: Multi-center retrospective analysis of 54 cases [J].
Oh, Sung Yong ;
Lee, Su-Jin ;
Lee, Jeeyun ;
Lee, Suee ;
Kim, Sung-Hyun ;
Kwon, Hyuk-Chan ;
Lee, Gyeong-Won ;
Kang, Lung Hun ;
Hwang, In Gyu ;
Jang, Joung-Soon ;
Lim, Ho Yeong ;
Park, Young Suk ;
Kang, Won Ki ;
Kim, Hyo-Lin .
WORLD JOURNAL OF GASTROENTEROLOGY, 2009, 15 (40) :5086-5090