Novel Immunotherapeutic Approaches to Treating HPV-Related Head and Neck Cancer

被引：11

作者：

Saba, Nabil F. F. ^{[1
]}

Pamulapati, Saagar ^{[2
]}

Patel, Bhamini ^{[3
]}

Mody, Mayur ^{[4
]}

Strojan, Primoz ^{[5
]}

Takes, Robert ^{[6
]}

Maekitie, Antti A. A. ^{[7
]}

Cohen, Oded ^{[8
]}

Pace-Asciak, Pia ^{[9
]}

Vermorken, Jan B. B. ^{[10
,11
]}

Bradford, Carol ^{[12
]}

Forastiere, Arlene ^{[13
]}

Teng, Yong ^{[1
]}

Wieland, Andreas ^{[12
,14
,15
]}

Ferlito, Alfio ^{[16
]}

机构：

[1] Emory Univ, Winship Canc Inst, Dept Hematol & Med Oncol, Atlanta, GA 30322 USA

[2] Mercyhealth, Internal Med Program, Rockford, IL 61114 USA

[3] Emory Univ, Dept Internal Med, Atlanta, GA 30307 USA

[4] AdventHlth Med Grp, Hematol & Oncol Program, Calhoun, GA 30701 USA

[5] Inst Oncol, Dept Radiat Oncol, Ljubljana 1000, Slovenia

[6] Radboud Univ Nijmegen, Med Ctr, Dept Otolaryngol & Head & Neck Surg, NL-6525 Nijmegen, Netherlands

[7] Univ Helsinki, Helsinki Univ Hosp, Dept Otorhinolaryngol Head & Neck Surg, Res Program Syst Oncol, FI-00014 Helsinki, Finland

[8] Ben Gurion Univ Negev, Soroka Med Ctr, Dept Otolaryngol, IL-84101 Beer Sheva, Israel

[9] Univ Toronto, Dept Otolarynol Head & Neck Surg, Toronto, ON M5S 1A1, Canada

[10] Antwerp Univ Hosp, Dept Med Oncol, B-2650 Edegem, Belgium

[11] Univ Antwerp, Fac Med & Hlth Sci, B-2610 Antwerp, Belgium

[12] Ohio State Univ, Dept Otolaryngol, Columbus, OH 43212 USA

[13] Johns Hopkins Univ, Sch Med, Dept Oncol, Baltimore, MD 21287 USA

[14] Ohio State Univ, Dept Microbial Infect & Immun, Columbus, OH 43210 USA

[15] Ohio State Univ, Comprehens Canc Ctr, Pelotonia Inst Immunooncol, Columbus, OH 43210 USA

[16] Int Head & Neck Sci Grp, I-35100 Padua, Italy

来源：

CANCERS | 2023年 / 15卷 / 07期

关键词：

human papillomavirus; HPV; immunotherapy; vaccine therapy; immuno-oncology; SQUAMOUS-CELL CARCINOMA; HUMAN-PAPILLOMAVIRUS HPV; METASTATIC HEAD; T-CELLS; OROPHARYNGEAL CANCER; DOSE CISPLATIN; PLUS CETUXIMAB; POSITIVE HEAD; SINGLE-ARM; OPEN-LABEL;

D O I：

10.3390/cancers15071959

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Head and neck cancer (HNC) is the seventh most common malignancy, with oropharyngeal squamous cell carcinoma (OPSCC) accounting for a majority of cases in the western world. While HNC accounts for only 5% of all cancers in the United States, the incidence of a subset of OPSCC caused by human papillomavirus (HPV) is increasing rapidly. The treatment for OPSCC is multifaceted, with a recently emerging focus on immunotherapeutic approaches. With the increased incidence of HPV-related OPSCC and the approval of immunotherapy in the management of recurrent and metastatic HNC, there has been rising interest in exploring the role of immunotherapy in the treatment of HPV-related OPSCC specifically. The immune microenvironment in HPV-related disease is distinct from that in HPV-negative OPSCC, which has prompted further research into various immunotherapeutics. This review focuses on HPV-related OPSCC, its immune characteristics, and current challenges and future opportunities for immunotherapeutic applications in this virus-driven cancer.

引用

页数：20

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