Effects of Exercise on Extracellular Vesicles in Patients with Metabolic Dystunction: a Systematic Review

被引：5

作者：

Li, Tong ^{[1
]}

Han, Xiaowan ^{[2
]}

Chen, Shiqi ^{[1
]}

Wang, Baofu ^{[1
]}

Teng, Yu ^{[1
]}

Cheng, Weiting ^{[1
]}

Lu, Ziwen ^{[1
]}

Li, Yang ^{[1
]}

Wu, Xiaoxiao ^{[1
]}

Jiang, Yangyang ^{[1
]}

Wang, Lei ^{[1
]}

Liu, Lisong ^{[2
]}

Zhao, Mingjing ^{[1
]}

机构：

[1] Beijing Univ Chinese Med, Dongzhimen Hosp, Minist Educ, Key Lab Chinese Internal Med, Beijing 100700, Peoples R China

[2] Beijing Univ Chinese Med, Dongzhimen Hosp, Dept Cardiac Rehabil, Beijing 100700, Peoples R China

来源：

JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH | 2023年 / 16卷 / 01期

基金：

中国国家自然科学基金;

关键词：

Extracellular vesicles; Exercise; Metabolic dysfunction; TYPE-2; DIABETES-MELLITUS; CORONARY-ARTERY-DISEASE; PHYSICAL-ACTIVITY; SKELETAL-MUSCLE; ENDOTHELIAL MICROPARTICLES; INSULIN SENSITIVITY; AEROBIC EXERCISE; SHORT-TERM; PLATELET; GLUCOSE;

D O I：

10.1007/s12265-022-10282-5

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The aim of this study was to investigate the effect of exercise on extracellular vesicles (EVs) in patients with metabolic dysfunction. The literatures were searched until Apr 28, 2022, and 16 studies that met inclusion criteria were included in this review. The results showed that the concentrations of platelet-derived extracellular vesicles (PEVs) and endothelial cellderived extracellular vesicles (EEVs) decreased after long-term exercise, especially for CD62E(+) EEVs and CD105(+) EEVs. Simultaneously, exercise improved the concentration of clinical evaluation indicators of metabolic diseases, and the changes in these indicators were positively correlated with the changes of EEVs and PEVs. The concentration of skeletal musclederived extracellular vesicles (SkEVs) increased after a single bout of exercise. The aforementioned results indicated that long-term exercise might improve endothelial function and hypercoagulability in patients with metabolic dysfunction. The changes in concentrations of EVs could assist in assessing effect of exercise on patients with metabolic dysfunction.

引用

页码：97 / 111

页数：15

共 110 条

[11] Diet, Exercise, and Endothelial Function in Obese Adolescents [J].

Bruyndonckx, Luc ;

Hoymans, Vicky Y. ;

De Guchtenaere, Ann ;

Van Helvoirt, Maria ;

Van Craenenbroeck, Emeline M. ;

Frederix, Geert ;

Lemmens, Katrien ;

Vissers, Dirk K. ;

Vrints, Christiaan J. ;

Ramet, Jose ;

Conraads, Viviane M. .

PEDIATRICS, 2015, 135 (03) :E653-E661

[12] High glucose increases the formation and pro-oxidative activity of endothelial microparticles [J].

Burger, Dylan ;

Turner, Maddison ;

Xiao, Fengxia ;

Munkonda, Mercedes N. ;

Akbari, Shareef ;

Burns, Kevin D. .

DIABETOLOGIA, 2017, 60 (09) :1791-1800

[13] Human obese white adipose tissue sheds depot-specific extracellular vesicles and reveals candidate biomarkers for monitoring obesity and its comorbidities [J].

Camino, Tamara ;

Lago-Baameiro, Nerea ;

Bravo, Susana Belen ;

Molares-Vila, Alberto ;

Sueiro, Aurelio ;

Couto, Ivan ;

Baltar, Javier ;

Casanueva, Eelipe F. ;

Pardo, Maria .

TRANSLATIONAL RESEARCH, 2022, 239 :85-102

[14] Hypercoagulability in overweight and obese subjects who are asymptomatic for thrombotic events [J].

Campello, Elena ;

Zabeo, Eva ;

Radu, Claudia M. ;

Spiezia, Luca ;

Gavasso, Sabrina ;

Fadin, Mariangela ;

Woodhams, Barry ;

Vettor, Roberto ;

Simioni, Paolo .

THROMBOSIS AND HAEMOSTASIS, 2015, 113 (01) :85-96

[15] Evidence for an independent and cumulative effect of postprandial hypertriglyceridemia and hyperglycemia on endothelial dysfunction and oxidative stress generation - Effects of short- and long-term simvastatin treatment [J].

Ceriello, A ;

Taboga, C ;

Tonutti, L ;

Quagliaro, L ;

Piconi, L ;

Bais, B ;

Da Ros, R ;

Motz, E .

CIRCULATION, 2002, 106 (10) :1211-1218

[16] Thrombin activity and platelet microparticle formation are increased in type 2 diabetic platelets: a potential correlation with caspase activation [J].

Cohen, Z ;

Gonzales, RF ;

Davis-Gorman, GF ;

Copeland, JG ;

McDonagh, PF .

THROMBOSIS RESEARCH, 2002, 107 (05) :217-221

[17]

Corcoran MP, 2007, AM J CLIN NUTR, V85, P662

[18] Circulating endothelial cell-derived extracellular vesicles mediate the acute phase response and sickness behaviour associated with CNS inflammation [J].

Couch, Yvonne ;

Akbar, Naveed ;

Roodselaar, Jay ;

Evans, Matthew C. ;

Gardiner, Chris ;

Sargent, Ian ;

Romero, Ignacio A. ;

Bristow, Adrian ;

Buchan, Alastair M. ;

Haughey, Norman ;

Anthony, Daniel C. .

SCIENTIFIC REPORTS, 2017, 7

[19] Methodological Guidelines to Study Extracellular Vesicles [J].

Coumans, Frank A. W. ;

Brisson, Alain R. ;

Buzas, Edit I. ;

Dignat-George, Francoise ;

Drees, Esther E. E. ;

El-Andaloussi, Samir ;

Emanueli, Costanza ;

Gasecka, Aleksandra ;

Hendrix, An ;

Hill, Andrew F. ;

Lacroix, Romaric ;

Lee, Yi ;

van Leeuwen, Ton G. ;

Mackman, Nigel ;

Maeger, Imre ;

Nolan, John P. ;

van der Pol, Edwin ;

Pegtel, D. Michiel ;

Sahoo, Susmita ;

Siljander, Pia R. M. ;

Sturk, Guus ;

de Wever, Olivier ;

Nieuwland, Rienk .

CIRCULATION RESEARCH, 2017, 120 (10) :1632-1648

[20] Endothelial Microparticles Act as Novel Diagnostic and Therapeutic Biomarkers of Diabetes and Its Complications: A Literature Review [J].

Deng, Fan ;

Wang, Shuang ;

Zhang, Liangqing .

BIOMED RESEARCH INTERNATIONAL, 2016, 2016

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