Mechanism of post-tetanic depression of slow muscle fibres

被引：1

作者：

Hoh, Joseph Foon Yoong ^{[1
,2
]}

机构：

[1] Univ Sydney, Fac Med & Hlth, Sch Med Sci, Discipline Physiol, Sydney, NSW 2006, Australia

[2] A2 Garnet St, Killara, NSW 2071, Australia

来源：

JOURNAL OF COMPARATIVE PHYSIOLOGY B-BIOCHEMICAL SYSTEMS AND ENVIRONMENTAL PHYSIOLOGY | 2024年 / 194卷 / 01期

关键词：

Muscle fibre types; Post-tetanic depression; Post-tetanic potentiation; Myosin-binding protein C; cAMP-dependent protein kinase; Calcineurin; BINDING-PROTEIN-C; LIGHT-CHAIN PHOSPHORYLATION; SKELETAL-MUSCLE; CARDIAC MYOSIN; FORCE; POTENTIATION; CONTRACTION; CALCINEURIN; TWITCH; TROPOMYOSIN;

D O I：

10.1007/s00360-024-01536-6

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

A brief tetanic stimulation has a very different effect on the subsequent isometric twitch force of fast and slow skeletal muscles. Fast muscle responds with an enhanced twitch force which doubles that of the pre-tetanic value, whereas slow muscle depresses the post-tetanic twitch by about 20%. Twitch potentiation of fast muscle has long been known to be due to myosin light chain 2 phosphorylation. It is proposed that post-tetanic twitch depression in slow muscle is due to the dephosphorylation of the slow isoform of the thick filament protein, myosin-binding protein-C, by Ca2+/calmodulin-activated phosphatase calcineurin, whilst its phosphorylation underlies the force enhancement due to beta-adrenergic stimulation in slow and fast muscle.

引用

页码：41 / 45

页数：5

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