Microwave-assisted synthesis of benzo[4,5]imidazo[1,2-a]pyrimidines and pyrano[4,3-b]pyrans catalyzed by L-glutamine functionalized magnetic nanoparticles in water:ethanol mixture

被引：4

作者：

Thongni, Aiborlang ^{[1
]}

Nongkhlaw, Rishanlang ^{[1
,4
]}

Pandya, Chayan ^{[2
]}

Sivaramakrishna, Akella ^{[2
]}

Gannon, Paige M. ^{[3
]}

Kaminsky, Werner ^{[3
]}

机构：

[1] North Eastern Hill Univ, Ctr Adv Studies Chem, Shillong, India

[2] Vellore Inst Technol VIT, Dept Chem, Vellore, India

[3] Univ Washington, Dept Chem, Seattle, WA USA

[4] North Eastern Hill Univ, Ctr Adv Studies Chem, Shillong 793022, India

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 2024年 / 61卷 / 04期

关键词：

ONE-POT SYNTHESIS; STRUCTURE-BASED DESIGN; IONIC LIQUID; PYRIMIDINE-DERIVATIVES; 3-COMPONENT SYNTHESIS; BIOLOGICAL EVALUATION; EFFICIENT SYNTHESIS; WATER; INHIBITORS; ACID;

D O I：

10.1002/jhet.4785

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

In this work, we report an effective, one-pot syntheses of benzo[4,5]imidazo[1,2-a]pyrimidine and pyrano[4,3-b]pyran derivatives using L-glutamine functionalized nanoparticles (Fe3O4@SiO2@L-glutamine NPs) under microwave irradiation. The organo-nanocatalyst underwent characterization through diverse techniques, including FT-IR, p-XRD, SEM, TEM, EDX, XPS, TGA, and VSM. Microwave irradiation and multicomponent reactions synergistically yield excellent product yields (approximate to 80%-95%) in shorter reaction times (approximate to 6-15 min) with a broader substrate scope. The organo-nanocatalyst displays notable catalytic efficacy, evidenced by high turnover numbers (TON) and turnover frequencies (TOF) across syntheses. This innovative protocol showcases exceptional efficiency, cost-effectiveness, and environmental friendliness, with advantages like minimal reaction conditions, easy catalytic recovery, recyclability, operational simplicity, and the use of eco-friendly solvents.

引用

页码：581 / 599

页数：19

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