Gasdermins: a dual role in pyroptosis and tumor immunity

被引:6
|
作者
Yang, Jiayi [1 ,2 ,3 ]
Jiang, Jingting [1 ,2 ,3 ]
机构
[1] Soochow Univ, Affiliated Hosp 3, Dept Tumor Biol Treatment, Changzhou, Jiangsu, Peoples R China
[2] Soochow Univ, Affiliated Hosp 3, Jiangsu Engn Res Ctr Tumor Immunotherapy, Changzhou, Jiangsu, Peoples R China
[3] Soochow Univ, Affiliated Hosp 3, Inst Cell Therapy, Changzhou, Jiangsu, Peoples R China
来源
FRONTIERS IN IMMUNOLOGY | 2024年 / 15卷
关键词
gasdermin; pyroptosis; caspase; granzyme; tumor immunity; immunotherapy; CELL-DEATH; EXPRESSION; CANCER; MECHANISMS; CLEAVAGE; GENES; GSDME;
D O I
10.3389/fimmu.2024.1322468
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
The gasdermin (GSDM) protein family plays a pivotal role in pyroptosis, a process critical to the body's immune response, particularly in combatting bacterial infections, impeding tumor invasion, and contributing to the pathogenesis of various inflammatory diseases. These proteins are adept at activating inflammasome signaling pathways, recruiting immune effector cells, creating an inflammatory immune microenvironment, and initiating pyroptosis. This article serves as an introduction to the GSDM protein-mediated pyroptosis signaling pathways, providing an overview of GSDMs' involvement in tumor immunity. Additionally, we explore the potential applications of GSDMs in both innovative and established antitumor strategies.
引用
收藏
页数:14
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