The Role of Brain-Derived Neurotrophic Factor (BDNF) in Depression and Cardiovascular Disease: A Systematic Review

被引:6
|
作者
Fioranelli, Massimo [1 ]
Roccia, Maria Grazia [1 ]
Przybylek, Bianca [2 ]
Garo, Maria Luisa [3 ]
机构
[1] Guglielmo Marconi Univ, Dept Human Sci, Via Plinio 44, I-00193 Rome, Italy
[2] Casa Cura Villa Rosario, Ist Terapie Sistem Integrate, Via Flaminia 449, I-00181 Rome, Italy
[3] Casa Cura Sanatrix, Ist Terapie Sistem Integrate, Via Trasone, 6, I-00199 Rome, Italy
来源
LIFE-BASEL | 2023年 / 13卷 / 10期
关键词
BDNF; brain-derived neurotrophic factor; cardiovascular disease; depression; POSTSTROKE DEPRESSION; MYOCARDIAL-INFARCTION; SERUM BDNF; STROKE; METAANALYSES; CONTRACTION; PLASTICITY; DISORDERS; SYMPTOMS; PROTECTS;
D O I
10.3390/life13101967
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
Background: Several studies have been conducted to prove the bidirectional relationship between cardiovascular disease (CVD) and depression. These two major illnesses share several common risk factors such that the development of either condition may increase the risk of the occurrence of the other. Brain-derived neurotrophic factor (BDNF) has been suggested as a reliable biomarker for depression and a strong predictor of CVD because it plays an important role in neuron survival and growth, serves as a neurotransmitter modulator, and promotes neuronal plasticity. The aim of this systematic review was to examine the bidirectional relationship between CVD and depression, focusing on the potential role of low serum BDNF levels in the development of either disease in the presence of the other. Methods: A systematic search strategy was developed using PRISMA guidelines. Results: Six studies (comprising 1251 patients) were identified, all of which examined the association between CVD and depression. Conclusions: It was found that there may be a strong association between low serum BDNF levels and the risk of post-stroke depression. However, the studies on the role of altered serum BDNF levels and other types of CVD are few. Therefore, the inverse association between depression and CVD cannot be proven.
引用
收藏
页数:16
相关论文
共 50 条
  • [21] Brain-derived neurotrophic factor (BDNF):: A key factor in schizophrenia?
    Guillin, O
    Griffon, N
    Krebs, MO
    Diaz, J
    Carroll, P
    Bourdel, MC
    Lôo, H
    Olié, JP
    Poirier, MF
    Schwartz, JC
    Sokoloff, P
    SCHIZOPHRENIA RESEARCH, 2002, 53 (03) : 105 - 105
  • [22] Phylogenesis of brain-derived neurotrophic factor (BDNF) in vertebrates
    Tettamanti, Gianluca
    Cattaneo, Anna Giulia
    Gornati, Rosalba
    de Eguileor, Magda
    Bernardini, Giovanni
    Binelli, Giorgio
    GENE, 2010, 450 (1-2) : 85 - 93
  • [23] BIOLOGICAL CHARACTERIZATION OF A BRAIN-DERIVED NEUROTROPHIC FACTOR (BDNF)
    BARDE, YA
    LINDSAY, RM
    THOENEN, H
    BIOLOGICAL CHEMISTRY HOPPE-SEYLER, 1985, 366 (04): : 324 - 324
  • [24] A narrative review of brain-derived neurotrophic factor (BDNF) on cognitive performance in Alzheimer's disease
    Ismail, Noor Azila
    Leong Abdullah, Mohammad Farris Iman
    Hami, Rohayu
    Ahmad Yusof, Hazwani
    GROWTH FACTORS, 2020, 38 (3-4) : 210 - 225
  • [25] Brain-Derived Neurotrophic Factor (BDNF) as a Potential Biomarker in Brain Glioma: A Systematic Review and Meta-Analysis
    Hasani, Fatemeh
    Masrour, Mahdi
    Khamaki, Sina
    Jazi, Kimia
    Ghoodjani, Erfan
    Teixeira, Antonio L.
    BRAIN AND BEHAVIOR, 2025, 15 (01):
  • [26] Brain-derived neurotrophic factor (BDNF) epigenomic modifications and brain-related phenotypes in humans: A systematic review
    Treble-Barna, Amery
    Heinsberg, Lacey W.
    Stec, Zachary
    Breazeale, Stephen
    Davis, Tara S.
    Kesbhat, Aboli A.
    Chattopadhyay, Ansuman
    VonVille, Helena M.
    Ketchum, Andrea M.
    Yeates, Keith Owen
    Kochanek, Patrick M.
    Weeks, Daniel E.
    Conley, Yvette P.
    NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS, 2023, 147
  • [27] Brain-Derived Neurotrophic Factor (BDNF) as an Indicator for Effects of Cognitive Behavioral Therapy (CBT): A Systematic Review
    Mosiolek, Anna
    Pietrzak, Magdalena
    Tabisz, Maria
    Wojtaszek, Wiktoria
    Zabielska, Michalina
    Ostrowska, Agnieszka
    Szwed, Pawel
    Mosiolek, Jadwiga
    Szulc, Agata
    BIOMEDICINES, 2023, 11 (01)
  • [28] Brain-derived neurotrophic factor (BDNF) as a potential marker of endometriosis: a systematic review and meta-analysis
    Jafarabady, Kyana
    Shafiee, Arman
    Bahri, Razman Arabzadeh
    Mohammadi, Ida
    Amini, Mohammad javad
    Rajai, Shahryar
    Akbarzadeh, Diba
    Abhari, Faeze Soltani
    Movahed, Emad
    Parvari, Soraya
    Bakhtiyari, Mahmood
    BMC WOMENS HEALTH, 2024, 24 (01)
  • [29] Brain-Derived Neurotrophic Factor (BDNF) as a Predictor of Treatment Response in Schizophrenia and Bipolar Disorder: A Systematic Review
    Liberona, Andres
    Jones, Natalia
    Zuniga, Karen
    Garrido, Veronica
    Zelada, Mario Ignacio
    Silva, Hernan
    Nieto, Rodrigo R.
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2024, 25 (20)
  • [30] Atopic dermatitis and anxiety: Possible role of brain-derived neurotrophic factor (BDNF)
    Cremona, Serena
    Dusi, Daniela
    Emanuele, Enzo
    Lossano, Cecilia
    MEDICAL HYPOTHESES, 2007, 68 (06) : 1419 - 1419